Aim: To investigate the protective effect of lipoxin A4 (LXA(4);) against rhabdomyolysis-induced acute kidney injury (AKI) and the possible mechanism.
Methods: The animal model of AKI was produced by intramuscular injection with glycerol. SD rats were randomly divided into 3 groups: the normal, AKI and LXA(4); groups. Blood urea nitrogen and serum creatinine levels were evaluated using a HITACHI 747 automatic analyzer. For histological examination, sections were stained with HE. The activity of myeloperoxidase (MPO) was detected by spectrophotometer. Expressions of TNF-α, IL-6 were determined by ELISA, and NF-κB in renal tissues was detected by Western blot analysis.
Results: The levels of blood urea nitrogen and serum creatinine decreased, and the injury of kidney was improved significantly in rats treated with LXA(4); as compared with AKI rats (P<0.05). The levels of TNF-α and IL-6, the activity of MPO and the expression of NF-κB were significantly lower in LXA(4); group than in AKI group (P<0.05).
Conclusion: LXA(4); can significantly protect rats against AKI partly by blocking NF-κB activation and reducing inflammatory cytokine expression and inflammatory cells infiltration in the kidney.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Extract Affects Acute Kidney Injury Caused by Rhabdomyolysis in Rats Through TNF/NF-κB Signaling Pathway.
Food Sci Nutr
January 2025
Department of Physiology, Faculty of Medicine Gonabad University of Medical Sciences Gonabad Iran.
Due to the anti-inflammatory and antioxidant properties of the and the pathological mechanisms of rhabdomyolysis in the kidney, this plant can be used to improve the symptoms of this disease. Then, in this study, we investigated the effects of this herb in improving kidney injury by rhabdomyolysis. Animals were divided into five groups: control, glycerol (received it for rhabdomyolysis induction), extract (received 12 mg/kg extract), and treatment groups with dexamethasone (0.
View Article and Find Full Text PDFAstragalus Polysaccharide Mitigates Rhabdomyolysis-Induced Acute Kidney Injury via Inhibition of M1 Macrophage Polarization and the cGAS-STING Pathway.
J Inflamm Res
December 2024
Department of Traditional Chinese Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, People's Republic of China.
Purpose: This study aimed to examine the impact of APS on acute kidney injury induced by rhabdomyolysis (RIAKI), exploring its association with macrophage M1 polarization and elucidating the underlying mechanisms.
Methods: C57BL/6J mice were randomly assigned to one of three groups: a normal control group, a RIAKI model group, and an APS treatment group. Techniques such as flow cytometry and immunofluorescence were employed to demonstrate that APS can inhibit the transition of renal macrophages to the M1 phenotype in RIAKI.
Understanding rhabdomyolysis induced acute kidney injury in patients with COVID-19.
World J Virol
December 2024
School of Medicine, Deakin University, Waurn Ponds, VIC 3216, Australia.
This work comments on an article published in the recent issue of the . Rhabdomyolysis is a complex condition with symptoms such as myalgia, changes to urination, and weakness. With the potential for substantial kidney impairment, it has also been shown to be a severe complication of coronavirus disease 2019 (COVID-19).
View Article and Find Full Text PDFNanoparticle Transport in Proximal Tubules with Rhabdomyolysis-Induced Necrosis.
Angew Chem Int Ed Engl
January 2025
Department of Chemistry and Biochemistry, The University of Texas at Dallas 800 W. Campbell Rd., Richardson, TX 75080, USA.
Article Synopsis
- Engineered nanoparticles designed for kidney disease treatment may target diseased kidney cells but require a better understanding of their accumulation at the cellular level to improve effectiveness and reduce side effects.* ! -
- Research using a mouse model with acute kidney injury showed that gold nanoparticles accumulate more in severely necrotic kidney cells, but their clearance is hindered by cellular debris during this late stage.* ! -
- The study highlights the importance of developing new nanoparticles that can effectively reach and be absorbed by damaged kidney cells before they experience extensive necrosis for better drug delivery outcomes.* !
Multiple site inflammation and acute kidney injury in crush syndrome.
Front Pharmacol
August 2024
Department of General Medicine Education, School of Medicine, Keio University, Tokyo, Japan.
Article Synopsis
- - Crush syndrome is a common consequence of earthquakes that can lead to acute kidney injury caused by muscle breakdown (rhabdomyolysis) and is worsened by systemic inflammatory response syndrome (SIRS).
- - A study using mice with rhabdomyolysis showed high levels of inflammatory markers in both serum and the peritoneal cavity, where inflammation was more pronounced in the peritoneum.
- - Administering a novel peptide that inhibits inflammation in the intraperitoneal cavity helped reduce muscle damage and kidney injury, suggesting that targeting inflammation in multiple areas could be beneficial for treatment.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!