We have found that N-cholinolytic drug benzohexonium produces a hypolipidemic effect: it reduces dyslipoproteinemia, fatty infiltration of the liver, and risk of atherosclerotic lesions.
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A new activity of N-cholinolytic drug benzohexonium.
Bull Exp Biol Med
August 2012
Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia. Ludmila.Konst83@ mail.ru
We have found that N-cholinolytic drug benzohexonium produces a hypolipidemic effect: it reduces dyslipoproteinemia, fatty infiltration of the liver, and risk of atherosclerotic lesions.
View Article and Find Full Text PDFAcetylcholine (ACh, 1 microM) stimulates activity of the contractile vacuole of proteus. The effect of ACh is not mimicked by its analogs which are not hydrolyzed by acetylcholinesterase (AChE), i. e.
View Article and Find Full Text PDFSexual function in adult male rats after prenatal modulation of the cholinergic system.
Neurosci Behav Physiol
June 2009
I. P. Pavlov St. Petersburg State Medical University, 6/8 L. Tolstoy Square, 197022, St. Petersburg, Russia.
Prenatal administration of the n-cholinolytic ganglerone to pregnant female rats at different periods of gestation was found to lead to long-term changes in sexual behavior in pubescent offspring: there was a reduced dynamic of acquiring sexual experience and a very low level of sexual activity, with significant impairment to the motivational and ejaculatory components of sexual behavior. The number of males with reduced sexual activity in the experimental groups was significantly greater than that in control offspring. The results obtained here provide evidence that impairments of sexual function in adult offspring induced by prenatal administration of the n-cholinolytic ganglerone at 9-11 and 12-14 days of gestation and, to a lesser extent, the m-cholinolytic metamyzil at 9-11 days of gestation, were due to impairment to the central mechanisms regulating sexual function due to stable changes in neurotransmitter activity in the hippocampus and hypothalamus, along with a significant reduction in the blood testosterone level.
View Article and Find Full Text PDF[The sexual function of mature rat males after prenatal modulation of cholinergic system].
Ross Fiziol Zh Im I M Sechenova
May 2008
The data obtained have shown that prenatal exposure of pregnant rat females of 9-19-day pregnancy to N-cholinolytics as compared to M-cholinolytics produce long-term behavioural changes in pubescent rat progeny. Pubescent rat progeny had low dynamics of gaining sexual experience and decreased sexual activity with equal disturbance of motivation and coitus. The number of males with absence of sexual activity was above that of the control group.
View Article and Find Full Text PDFInvolvement of N-cholinergic synapses in regulating RNA metabolism in sympathetic neurons and satellite gliocytes.
Neurosci Behav Physiol
February 2008
Department of Nervous System Embryology, Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow.
RNA contents in the cytoplasm of neurons and satellite gliocytes in the cranial cervical ganglion of rabbits were determined by photographic cytophotometry during pharmacological blockade of N-cholinergic (N-Ch) synapses with the N-cholinolytic dimecoline (s.c. doses of 10, 30, and 50 mg/kg) and during the gradual decrease and elimination of blockade (1-11 h after dosage).
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