In this work, we demonstrate 3-D photoacoustic imaging of optically absorbing targets embedded as deep as 5 cm inside a highly scattering background medium using a 2-D capacitive micromachined ultrasonic transducer (CMUT) array with a center frequency of 5.5 MHz. 3-D volumetric images and 2-D maximum intensity projection images are presented to show the objects imaged at different depths. Due to the close proximity of the CMUT to the integrated frontend circuits, the CMUT array imaging system has a low noise floor. This makes the CMUT a promising technology for deep tissue photoacoustic imaging.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438520 | PMC |
http://dx.doi.org/10.1109/ULTSYM.2010.5935647 | DOI Listing |
Acta Pharm Sin B
December 2024
Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Cervical cancer, the most common gynecological malignancy, significantly and adversely affects women's physical health and well-being. Traditional surgical interventions and chemotherapy, while potentially effective, often entail serious side effects that have led to an urgent need for novel therapeutic methods. Photothermal therapy (PTT) has emerged as a promising approach due to its ability to minimize damage to healthy tissue.
View Article and Find Full Text PDFJ Biophotonics
January 2025
The Richard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, Illinois, USA.
The use of photoacoustic brain imaging for hemorrhage detection holds significant clinical importance. This study focuses on the performance of sensitivity and detection capabilities of a single-element scanning system, considering the remarkable signal-to-noise ratio of photoacoustic signals generated by a single-element transducer. By employing blood vessel-like phantoms and ex vivo brain phantoms, we demonstrated the superior efficacy of the single-element scanning method over the transducer array system in the context of brain hemorrhage detection.
View Article and Find Full Text PDFPhotoacoustics
February 2025
Institute of Fiber Optics, Shanghai University, Shanghai 201800, China.
Photoacoustic imaging (PAI) is an emerging hybrid imaging technology that combines the advantages of optical and ultrasound imaging. Despite its excellent imaging capabilities, PAI still faces numerous challenges in clinical applications, particularly sparse spatial sampling and limited view detection. These limitations often result in severe streak artifacts and blurring when using standard methods to reconstruct images from incomplete data.
View Article and Find Full Text PDFJ Mater Chem B
January 2025
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
The therapeutic diagnosis of liver diseases has garnered significant interest within the medical community. In recent years, mesoporous silica nanoparticles (MSNs) have emerged as crucial nanocarriers for the treatment of liver ailments. Their remarkable diagnostic capabilities enable them to be used in techniques such as high-throughput mass spectrometry (MS), magnetic resonance imaging (MRI), near-infrared (NIR) fluorescence imaging, photoacoustic imaging (PAI), and ultrasonography (US), attracting considerable attention.
View Article and Find Full Text PDFPhys Med Biol
January 2025
North China Electric Power University - Baoding Campus, North China Electric Power University, Baoding, Hebei Province, P.R.China, Baoding, Hebei, 071003, CHINA.
Objective: The optical absorption properties of biological tissues in photoacoustic tomography are typically quantified by inverting acoustic measurements. Conventional approaches to solving the inverse problem of forward optical models often involve iterative optimization. However, these methods are hindered by several challenges, including high computational demands, the need for regularization, and sensitivity to both the accuracy of the forward model and the completeness of the measurement data.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!