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Injury induced endotheliopathy: overview, diagnosis, and management.
Curr Opin Crit Care
January 2025
Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Purpose Of Review: This review aims to examine recent advances in the understanding of injury-induced endotheliopathy and therapeutics to mitigate its development in critically injured patients.
Recent Findings: Clinical studies have clearly demonstrated that syndecan-1 ectodomains can be found in circulation after various types of trauma and injury and correlates with worse outcomes. As the mechanisms of endotheliopathy are better understood, pathologic hyperadhesive forms of von Willebrand factor, along with a relative deficiency of its cleaving enzyme, a disintegrin and metalloprotease with thrombospondin type I motifs, member 13 (ADAMTS13), have emerged as additional biomarkers.
Freeze-dried plasma: Hemostasis and biophysical analyses for damage control resuscitation.
Transfusion
January 2025
Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Background: Effective hemorrhage protocols prioritize immediate hemostatic resuscitation to manage hemorrhagic shock. Prehospital resuscitation using blood products, such as whole blood or alternatively dried plasma in its absence, has the potential to improve outcomes in hemorrhagic shock patients. However, integrating blood products into prehospital care poses substantial logistical challenges due to issues with storage, transport, and administration in field environments.
View Article and Find Full Text PDFTherapeutic targets for hepatocellular carcinoma identified using proteomics and Mendelian randomization.
J Gastroenterol Hepatol
October 2024
The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a serious cancer with high rates of illness and death, driving research into new treatment targets through gene-protein relationships.
- * In this study, researchers analyzed data from multiple sources to identify 10 proteins associated with HCC risk, highlighting the importance of proteins like TFPI2 and ALDH1A1.
- * The findings suggest that targeting these proteins could lead to new therapies for HCC and contribute to the overall fight against cancer.
A comparative study of anti-ADAMTS-13 antibody dynamics in immune-mediated thrombotic thrombocytopenic purpura.
Res Pract Thromb Haemost
July 2024
Centro di Riferimento Oncologico (CRO) Aviano, National Cancer Institute, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Immunopathology and Cancer Biomarkers Unit, Department of Cancer Research and Advanced Diagnostics, Aviano, Italy.
Background: Thrombotic thrombocytopenic purpura, particularly its immune-mediated variant (iTTP), necessitates accurate diagnostic approaches for effective management.
Objectives: To compare a chemiluminescence immunoassay (CLIA) and an enzyme-linked immunosorbent assay (ELISA) for testing ADAMTS-13 activity and detecting anti-ADAMTS-13 autoantibodies (AAbs) in patients with iTTP.
Methods: This study involved 31 paired samples from 12 iTTP patients.
Diagnostic Challenges in a Case of Immune-Mediated Thrombotic Thrombocytopenic Purpura With Severe ADAMTS13 Deficiency.
Cureus
August 2024
Internal Medicine, Honduran Social Security Institute, San Pedro Sula, HND.
Article Synopsis
- * A case study of a 23-year-old male patient reveals symptoms like altered mental status, hemolytic anemia, and acute kidney injury, highlighting the complexities in diagnosing TTP, particularly in distinguishing it from similar conditions like hemolytic uremic syndrome (HUS).
- * The study emphasizes the need for better diagnostic tools in Honduras, particularly ADAMTS13 testing, to improve accurate and timely diagnosis and treatment of TTP.
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