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Clomipramine-Induced Urinary Retention in an Adult Male - A Case Report.
Curr Drug Saf
January 2025
Department of Pharmacology, Government Medical College, Bhavnagar, India.
Background: Clomipramine, a Tricyclic Antidepressant (TCA), is known for its efficacy in treating Obsessive-compulsive Disorder (OCD). However, it is associated with several side effects, including urinary retention. This case report discusses the case of a 20-year-old male with OCD who developed urinary retention following clomipramine administration.
View Article and Find Full Text PDFTreatment of Obsessive-Compulsive Disorder in Children and Youth: A Meta-Analysis.
Pediatrics
December 2024
Center for Evidence Synthesis in Health, Department of Health Services, Policy, and Practice, Brown University School of Public Health, Brown University, Warren Alpert Medical School, Providence, Providence, RI.
Context: Treatments for obsessive-compulsive disorder (OCD) in children and adolescents.
Objective: Evaluate the comparative efficacy of behavioral and pharmacologic treatments.
Data Sources: Six databases and ClinicalTrials.
Machine learning in obsessive-compulsive disorder medications.
Heliyon
November 2024
Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Obsessive-compulsive disorder (OCD) is the fourth most common psychiatric disorder with a significant morbidity rate. Despite various treatment modalities and medications, some patients show no definitive response. The aim of this study is to classify the medications of OCD with machine learning (ML) methods and to compare the classification performances of the decision tree (DT), chi-square automatic interaction detection (CHAID) algorithm, and linear model in ML methods.
View Article and Find Full Text PDF[Translated article] Trichotillomania Treatment Update.
Actas Dermosifiliogr
November 2024
Trichology Unit, Grupo de Dermatología Pedro Jaén, Madrid, Spain; Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Departamento de Biología de Sistemas, Facultad de Medicina, Universidad de Alcalá, IRYCIS, Madrid, Spain.
Trichotillomania (TTM) is an obsessive-compulsive disorder in which affected individuals recurrently pull-out hair from any region of the body, causing hair loss or alopecia. The management of TTM is a therapeutic challenge for dermatologists and consists of a combination of pharmacological and non-pharmacological alternatives. Cognitive-behavioral therapy has successfully been used to treat TTM.
View Article and Find Full Text PDFSingle-dose and steady-state pharmacokinetics of clomipramine, yohimbine and clomipramine/yohimbine combination: A clinical drug-drug interaction study.
Br J Clin Pharmacol
October 2024
Department of Clinical Pharmacology, Medical University of Vienna, Austria.
Article Synopsis
- Clomipramine (CLOMI) is effective for premature ejaculation but may cause erectile dysfunction, while yohimbine (YOH) helps with erectile dysfunction and could boost libido; combining both drugs may harness their benefits.
- In a study with 15 healthy male subjects, researchers analyzed how these drugs interact when taken together, assessing their pharmacokinetics and safety profiles through various plasma sampling methods.
- Results indicated a significant interaction with YOH when combined with CLOMI, suggesting competitive inhibition of YOH metabolism by CLOMI, but this interaction is considered minor according to regulatory guidelines, which supports further studies on their combined efficacy.
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