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Genome-wide transcription responses to synchrotron microbeam radiotherapy. | LitMetric

Genome-wide transcription responses to synchrotron microbeam radiotherapy.

Radiat Res

Centre for Innate Immunity and Infectious Disease, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia.

Published: October 2012

AI Article Synopsis

  • - The study examines how different types of radiotherapy—specifically synchrotron-generated X-ray microbeam radiotherapy and traditional broad beam irradiation—affect tumor responses at the molecular level.
  • - Researchers hypothesized that microbeam radiotherapy would cause unique changes in gene expression compared to broad beam methods.
  • - Results showed that microbeam radiotherapy differentially regulates several genes related to immune response and tumor control, highlighting important biological differences in how tumors respond to these two forms of treatment.

Article Abstract

The majority of cancer patients achieve benefit from radiotherapy. A significant limitation of radiotherapy is its relatively low therapeutic index, defined as the maximum radiation dose that causes acceptable normal tissue damage to the minimum dose required to achieve tumor control. Recently, a new radiotherapy modality using synchrotron-generated X-ray microbeam radiotherapy has been demonstrated in animal models to ablate tumors with concurrent sparing of normal tissue. Very little work has been undertaken into the cellular and molecular mechanisms that differentiate microbeam radiotherapy from broad beam. The purpose of this study was to investigate and compare the whole genome transcriptional response of in vivo microbeam radiotherapy versus broad beam irradiated tumors. We hypothesized that gene expression changes after microbeam radiotherapy are different from those seen after broad beam. We found that in EMT6.5 tumors at 4-48 h postirradiation, microbeam radiotherapy differentially regulates a number of genes, including major histocompatibility complex (MHC) class II antigen gene family members, and other immunity-related genes including Ciita, Ifng, Cxcl1, Cxcl9, Indo and Ubd when compared to broad beam. Our findings demonstrate molecular differences in the tumor response to microbeam versus broad beam irradiation and these differences provide insight into the underlying mechanisms of microbeam radiotherapy and broad beam.

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Source
http://dx.doi.org/10.1667/RR2885.1DOI Listing

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