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http://dx.doi.org/10.1080/15265161.2012.711899 | DOI Listing |
Neurochem Res
January 2025
Precision Pharmacy & Drug Development Center, Department of Pharmacy, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, China.
Depression is a common and complex neuropsychiatric disorder affecting people of all ages worldwide, associated with high rates of relapse and disability. Neohesperidin (NEO) is a dietary flavonoid with applications in therapeutics; however, its effects on depressive-like behavior remain unknown. Here, we evaluated the effects of NEO on depressive-like behavior induced by chronic and unpredictable mild stress (CUMS).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.
Background: Circadian rhythm disorder is not only a characteristic of neurodegenerative diseases but may participate in driving the pathological development in early stages of these diseases. Transactive response DNA-binding protein of 43 kDa (TDP-43) knockdown and its pathological aggregation are associated with severe neurodegenerative diseases such as amyotrophic lateral sclerosis.
Methods: C57BL/6 mice were sleep deprived and sarcrificed at ZT0, ZT6, ZT12, and ZT18 and detected by Western blots.
Alzheimers Dement
December 2024
Universidade Federal de São Paulo (UNIFESP), São Paulo, São Paulo/SP, Brazil.
Background: Subjective Memory Complaints (SMC) are common with aging and might be associated with objective memory impairment (MI) and with higher risk to develop dementia. This association is understudied in socially and ethnically diverse populations, such as Brazilians.
Method: This study uses the baseline data from the ELSI-Brazil, a representative sample of 9402 Brazilians over 50 years.
Front Immunol
January 2025
Pharmacy Department, Weihai Central Hospital Affiliated to Qingdao University, Weihai, China.
Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes associated with high mortality and disability rates. Inflammation has emerged as a key pathological mechanism in DKD, prompting interest in novel therapeutic approaches targeting inflammatory pathways. Interleukin-6 (IL-6), a well-established inflammatory cytokine known for mediating various inflammatory responses, has attracted great attention in the DKD field.
View Article and Find Full Text PDFFront Rehabil Sci
December 2024
Community Oriented Primary Care (COPC) Research Unit, Faculty of Health Sciences, University of Pretoria, Tshwane, South Africa.
South Africa faces the detrimental effects of problematic substance use. The Community Oriented Substance Use Program (COSUP) is a research-based, community-situated harm-reduction program. The International Classification of Functioning, Disability and Health (ICF) was used as the framework to develop a unique tool to determine the functioning of COSUP clients.
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