AI Article Synopsis
- oPOSSUM-3 is a web-based tool that identifies over-represented transcription factor binding sites (TFBS) in DNA sequences, particularly useful for co-expressed genes and high-throughput data like ChIP-Seq.
- The system has been validated using known co-regulated gene sets and existing ChIP-Seq data, proving its ability to pinpoint transcription factors involved with these genes.
- You can access oPOSSUM-3 online at http://opossum.cisreg.ca.
Article Abstract
oPOSSUM-3 is a web-accessible software system for identification of over-represented transcription factor binding sites (TFBS) and TFBS families in either DNA sequences of co-expressed genes or sequences generated from high-throughput methods, such as ChIP-Seq. Validation of the system with known sets of co-regulated genes and published ChIP-Seq data demonstrates the capacity for oPOSSUM-3 to identify mediating transcription factors (TF) for co-regulated genes or co-recovered sequences. oPOSSUM-3 is available at http://opossum.cisreg.ca.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429929 | PMC |
| http://dx.doi.org/10.1534/g3.112.003202 | DOI Listing |
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