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Genome-wide association study reveals heat tolerance QTL for canopy-closure and early flowering in chickpea.
Front Plant Sci
December 2024
School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.
Chickpeas are a vital source of protein and starch for a large portion of the world's population and are known to be impacted by heat stress at every life stage. Previously known as an "Orphan Legume", little is known of the genetic control of heat stress tolerance, and most previous research has focused on heat avoidance rather than tolerance. This study utilised a population of 148 chickpea genotypes, primarily Kabulis, in 12 field trials conducted at 2 locations, two sowing periods, and across 3 years.
View Article and Find Full Text PDFAcid sphingomyelinase deficiency (ASMD) is a rare progressive genetic disorder caused by pathogenic variants in the gene causing low or absent activity of the enzyme acid sphingomyelinase, resulting in subsequent accumulation of its substrate, sphingomyelin. Signs and symptoms of excessive lysosomal sphingomyelin storage, such as hepatosplenomegaly and pulmonary impairment, and in a subset of patients, progressive neurological manifestations, have long been recognized as hallmarks of the disease. Uncontrolled accumulation of sphingomyelin has important and complex downstream metabolic and immunologic consequences that contribute to the disease burden.
View Article and Find Full Text PDFA brief history of insect neuropeptide and peptide hormone research.
Cell Tissue Res
December 2024
Department of Zoology, Stockholm University, S-10691, Stockholm, Sweden.
This review briefly summarizes 50 years of research on insect neuropeptide and peptide hormone (collectively abbreviated NPH) signaling, starting with the sequencing of proctolin in 1975. The first 25 years, before the sequencing of the Drosophila genome, were characterized by efforts to identify novel NPHs by biochemical means, mapping of their distribution in neurons, neurosecretory cells, and endocrine cells of the intestine. Functional studies of NPHs were predominantly dealing with hormonal aspects of peptides and many employed ex vivo assays.
View Article and Find Full Text PDFEfficacy and safety of filgotinib as induction and maintenance therapy for Crohn's disease (DIVERSITY): a phase 3, double-blind, randomised, placebo-controlled trial.
Lancet Gastroenterol Hepatol
February 2025
Department of Gastroenterology and Digestive Endoscopy, IRCCS Hospital San Raffaele, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
Background: There is a need for efficacious therapies for patients with Crohn's disease that are better tolerated and more durable than available treatments. We aimed to evaluate the efficacy and safety of filgotinib, an oral Janus kinase 1 preferential inhibitor, for treating Crohn's disease.
Methods: This phase 3, double-blind, randomised, placebo-controlled trial was conducted in 371 centres in 39 countries.
Indirect Treatment Comparisons in Healthcare Decision Making: A Targeted Review of Regulatory Approval, Reimbursement, and Pricing Recommendations Globally for Oncology Drugs in 2021-2023.
Adv Ther
November 2024
EVERSANA™, Burlington, ON, Canada.
Introduction: Indirect treatment comparisons (ITCs) evaluate novel treatments compared to appropriate comparators when direct evidence is unavailable or infeasible. The objective of this study was to highlight the prevalence of different ITC methods in oncology drug submissions and to provide insights into how ITCs have been used in recent regulatory approval, reimbursement recommendations, or pricing decisions across various regions and diverse assessment frameworks.
Methods: A targeted literature review was conducted to identify assessment documents for oncology drug submissions that included ITCs.
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