AI Article Synopsis
- Acute promyelocytic leukemia (APL) is a rare but malignant form of leukemia usually caused by a specific genetic fusion; it's more common in adults than children.
- A 1-year-old boy was diagnosed with APL after presenting with a mass in the jaw, where imaging suggested it could be a serious tumor.
- Treatment with tretinoin was successful, and there have been no signs of recurrence after one year.
Article Abstract
Background: Acute promyelocytic leukemia (APL) is a malignant subtype of acute myeloid leukemia caused by the PML-retinoic acid receptor (RAR)α fusion gene. APL may be discovered in adulthood and diagnosed after spontaneous gingival bleeding or difficulty in hemostasis after oral surgery such as tooth extraction. However, APL is extremely rare in children.
Methods And Results: A 1-year-old boy presented with a mass on the mentum of the mandible. The marked periosteal reaction was seen on CT and MRI, leading to strong suspicion of a malignant bone-derived tumor such as a sarcoma. Chromosome banding by fluorescence in situ hybridization (FISH) showed PML-RARα, confirming the diagnosis of APL. Treatment with tretinoin was immediately initiated. No signs of recurrence have been noted 1 year after treatment.
Conclusions: We report herein a rare case involving an infant with APL who presented with an extramedullary tumor of the mandible, whom we treated with good results.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hed.23163 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!