In nonsense-mediated mRNA decay (NMD), large protein complexes cooperate to trigger degradation of mRNA with a premature termination codon. Due to the extreme variation in the size and topology of its mRNA substrate, the structural underpinning of the fidelity of NMD is little understood. Based on bioinformatic predictions, we suggest that fly-casting mechanisms enabled by long disordered regions in NMD complexes are exploited for the underlying effective long-range communication.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jmb.2012.09.002 | DOI Listing |
Publication Analysis
Top Keywords
nonsense-mediated mrna
8
mrna decay
8
long-range interactions
4
interactions nonsense-mediated
4
mrna
4
decay mediated
4
mediated intrinsically
4
intrinsically disordered
4
disordered protein
4
protein regions
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!