The title compound, C(11)H(11)Br(2)NO(4)·0.5H(2)O, was prepared by an electrophilic bromination of N-acetyl-l-tyrosine in acetonitrile at room temperature. The two independent mol-ecules do not differ substanti-ally and a mol-ecule of water completes the asymmetric unit. The synthesis of the title compound does not modify the stereochemical center, as shown by the absolute configuration found in this crystal structure. Comparison with the non-bromo starting material differs mainly by rotation features. For instance the H(methine)-C(chiral center)-C(methyl-ene)-C(ipso) is 173.0 (2)° torsion angle in one mol-ecule and 177.3 (2)° in the other, indicating a trans arrangement. This is in contrast with approximately 50° in the starting material. A short inter-molecular Br⋯Br separation is observed [3.2938 (3) Å]. The molecules in the crystal are connected via a network of hydrogen bonds through an N-H⋯O hydrogen bond between the hydroxy group of the phenol of the tyrosine and the N-H of the amide of the other molecule and an O-H⋯O hydrogen bond between the hydroxy group of the carboxylic acid and the oxygen of the carbonyl of the amide.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435634 | PMC |
| http://dx.doi.org/10.1107/S1600536812032928 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ruthenium-Hydride Complexes Facilitated Sustainable Synthesis of Isoxazolones via Acceptorless Dehydrogenative Annulation of Alcohols.
J Org Chem
January 2025
Centre for Organometallic Chemistry, School of Chemistry, Bharathidasan University, Tiruchirappalli 620 024, India.
A streamlined strategy for the one-pot synthesis of isoxazolone analogues has been developed through an acceptorless dehydrogenative annulation (ADA) pathway by employing new Ru(II) hydride complexes as effective catalysts. New Ru(II) complexes () tailored with N̂O chelating carbazolone benzhydrazone ligands were synthesized and their formation was confirmed using analytical and spectral techniques including FT-IR and NMR. The structural configuration of the complexes featuring an octahedral geometry around the Ru(II) ion was precisely determined by single-crystal X-ray diffraction analysis.
View Article and Find Full Text PDFCancer Organoids as reliable disease models to drive clinical development of novel therapies.
J Exp Clin Cancer Res
December 2024
Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
On September 23-24 (2024) the 6th Workshop IRE on Translational Oncology, titled "Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies," took place at the IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused on tumor organoids, bringing together leading experts from around the world.A central challenge in precision oncology is modeling the dynamic tumor ecosystem, which encompasses numerous elements that evolve spatially and temporally.
View Article and Find Full Text PDFCrown-Ether Coordination Compounds of Europium and 24-Crown-8.
Inorg Chem
December 2024
Institute of Inorganic Chemistry (IAC), Karlsruhe Institute of Technology (KIT), Engesserstraße 15, D-76131 Karlsruhe, Germany.
Crown-ether coordination compounds of europium(II/III) and the crown ether (CHO) (24-crown-8, 24c8) are prepared, aiming at novel compounds, structures, and coordination modes as well as potential luminescence properties. By reacting EuCl, EuI, or EuCl with 24c8 or its derivatives in ionic liquids, the novel compounds [BuMeN][Eu(II)(NTf)] (), [BMIm][EuI] (), [EuCl(dibenzo-18c6)] (), [EuI(dibenzo-24c8)] (), [(Eu(III)Cl)(CHO)](24c8) (), and [Eu(III)Cl(24c8)]I () are obtained (BMIm: 1-butyl-3-methylimidazolium; EMIm: 1-ethyl-3-methylimidazolium). Based on different reaction conditions, different coordinative modes including the absence of the crown ether in the product (, ), splitting of the crown ether (), and coordination of 24c8 via six of eight oxygen atoms () and, finally, via all oxygen atoms () are observed.
View Article and Find Full Text PDFNew benzimidazole-indole-amide derivatives as potent α-glucosidase and acetylcholinesterase inhibitors.
Arch Pharm (Weinheim)
January 2025
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
New derivatives 6a-m with benzimidazole-indole-amide scaffold were developed, synthesized, and assessed for potential inhibitory effects on α-glucosidase and acetylcholinesterase (AChE). These compounds were synthesized by various amine derivatives. With the exception of two compounds, the α-glucosidase inhibitory activities of the title derivatives were more than that of the positive control acarbose.
View Article and Find Full Text PDFRisk assessment of food additives including dietary exposure.
EFSA J
December 2024
Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Facultad de Farmacia Universidad de Sevilla Sevilla Spain.
Lately, the entire society's focus has turned towards consuming more natural food products and the production of chemicals obtained utilising green technologies. The use of chemicals as food additives is a concern for consumers. For this reason, the search for natural and more sustainable additives is a key step to control food risks while meeting consumers' requirements.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!