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Ocular Manifestation of Granulomatosis with Polyangiitis Presenting as Serous Retinal Detachment: A Case Report.
Medicina (Kaunas)
October 2024
Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University, Seoul 02447, Republic of Korea.
: Ocular involvement is relatively common in granulomatosis with polyangiitis (GPA); however, choroidal involvement is rare. We present a case of serous retinal detachment resulting from choroidal involvement in GPA. : A 55-year-old male presented to our clinic with bilateral eye redness and pain.
View Article and Find Full Text PDFGranulomatosis with Polyangiitis Discovered Because of Repeated Upper Eyelid Swelling.
Medicina (Kaunas)
September 2024
Department of Ophthalmology, Asahi General Hospital, Chiba 289-2511, Japan.
Article Synopsis
- - A 25-year-old woman experienced persistent swelling and redness in her left eye, initially misdiagnosed as common conditions like hordeolum or eyelid cellulitis due to resistance to treatment.
- - Blood tests revealed positivity for PR3-ANCA, leading to a diagnosis of granulomatosis with polyangiitis (GPA), despite the lack of systemic symptoms in typical areas like the lungs or kidneys.
- - The case highlights the difficulties in diagnosing GPA when it presents as isolated ocular lesions, emphasizing the need to consider this condition in young patients with treatment-resistant eye issues.
Sight-Threatening Unilateral Posterior Scleritis With Positive Atypical p-ANCA As Early Manifestation of Lupus Spectrum Disease.
Cureus
April 2024
Department of Ophthalmology, Hospital Ampang, Selangor, MYS.
Antinuclear cytoplasmic antibody (ANCA)-related scleritis is a potentially sight-threatening inflammatory condition that may occur as a primary vasculitis disorder or as a secondary vasculitis in a variety of inflammatory conditions. While ANCA has been classically associated with primary vasculitis diseases such as granulomatosis with polyangiitis (GPA), microscopic polyarteritis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA), it is interesting that in cases of lupus spectrum disease (LSD), both ANCA and atypical p-ANCA have been observed as secondary autoantibodies. Scleritis is a rare ocular manifestation of lupus disease with an incidence of around 1%.
View Article and Find Full Text PDFA case of granulomatosis with polyangiitis-associated scleritis presenting as conjunctivitis.
Oman J Ophthalmol
February 2024
Department of Uvea, Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, Tamil Nadu, India.
A 42-year-old male presented initially with conjunctivitis and was treated with topical medical medications without any improvement. He developed ocular pain subsequently and further examination revealed lid edema, conjunctival hyperemia with chemosis, matting of lashes with yellowish discharge, and deeper episcleral congestion which did not blanch with topical vasoconstrictor. Subsequent laboratory investigation revealed positive cytoplasmic-antineutrophil cytoplasmic antibody (Anti-PR 3 antibody).
View Article and Find Full Text PDFOcular manifestations of granulomatosis with polyangiitis: report from a tertiary eye care center.
Int Ophthalmol
February 2024
Department of Ophthalmology, Ege University Medical Faculty Hospital, 35100, Bornova, Izmir, Turkey.
Purpose: To report demographic characteristics and ophthalmological manifestations of patients with granulomatosis with polyangiitis (GPA) in a tertiary eye care center in Turkey.
Methods: Medical records of patients with GPA-related ocular manifestations evaluated between 2013 and 2023 were included. Demographic and clinical characteristics of the patients including nature of systemic involvement, ophthalmologic symptoms and signs, laboratory investigations and treatment modality were reviewed.
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