Elderly adults should perform exercises that maintain or improve balance to reduce risk of injury from falls. Bone fractures secondary to falls in the elderly, particularly sedentary females, continue to pose a major health and economic problem. A greater understanding of the processes that contribute to the propensity for falling may be obtained by considering changes in gait biodynamics with age and activity level. Therefore, the purpose of this study was to quantify the relationships between age/activity level and selected biodynamic parameters of the lower extremity during normal gait. Seventeen healthy women, 9 young and 8 elderly, were divided into groups of 9 active and 8 sedentary subjects. Three-dimensional (3D) video motion and force platform kinematic and kinetic data were collected from the hip, knee, and ankle of the right lower extremity as the subjects walked at self-selected speeds. Data were analyzed as functions of age and activity level by using a 2-way analysis of variance. As expected, our results show that the elderly group had significantly greater (p < 0.05) functional and mobility limitations in their lower extremity joints than did the younger group. Significant, age-related lower-limb gait alterations were manifested primarily at the ankle, whereas activity-related alterations were manifested most prominently at the hip. The knee showed the fewest changes accompanying age or activity level. Thus, age and activity level affect gait, which may have a role in the subsequent development of a predisposition to gait-related imbalances and resultant falling and increased hip fracture risk. Strength and conditioning professionals may consider these factors related to age and activity level when individualizing exercise regimens for their older, or sedentary, clients. Prophylactic physical activities involving specific, controlled 3D body movements may help prevent abnormal lower-limb joint kinematics (and their hypothetically coupled, intrinsic postural control strategies), thereby reducing fall and fracture propensity.
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http://dx.doi.org/10.1519/JSC.0b013e318269f83d | DOI Listing |
JAMA Netw Open
January 2025
University Centre for Rural Health, School of Health Sciences, University of Sydney, Lismore, New South Wales, Australia.
Importance: An unhealthy lifestyle is believed to increase the development and persistence of low back pain, but there is uncertainty about whether integrating support for lifestyle risks in low back pain management improves patients' outcomes.
Objective: To assess the effectiveness of the Healthy Lifestyle Program (HeLP) compared with guideline-based care for low back pain disability.
Design, Setting, And Participants: This superiority, assessor-blinded randomized clinical trial was conducted in Australia from September 8, 2017, to December 30, 2020, among 346 participants who had activity-limiting chronic low back pain and at least 1 lifestyle risk (overweight, poor diet, physical inactivity, and/or smoking), referred from hospital, general practice, and community settings.
Mol Biol Rep
January 2025
Department of Pathology and Laboratory Medicine, Baylor Scott and White Medical Center, Baylor College of Medicine, Temple, TX, USA.
Background: Brain intraparenchymal schwannoma is a rare clinical entity, generally curable with adequate resection.
Methods And Results: We describe a case in a male patient first presenting at 19 months of age, the youngest reported age for this lesion. It also appears to be the first case connected to a germline TSC2 p.
Am J Physiol Endocrinol Metab
January 2025
Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, 97239.
Maternal obesity puts the offspring at high risk of developing obesity and cardio-metabolic diseases in adulthood. Here, we utilized a mouse model of maternal high-fat diet (HFD)-induced obesity that recapitulates metabolic perturbations seen in humans. We show increased adiposity in the offspring of HFD-fed mothers (Off-HFD) when compared to the offspring regular diet-fed mothers (Off-RD).
View Article and Find Full Text PDFTransl Vis Sci Technol
January 2025
Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Purpose: Alteration of visual acuity in wet age-related macular degeneration (AMD) is mostly driven by vascular endothelial growth factor A (VEGF-A)-induced edema from leaky newly forming blood vessels below the retina layers. To date, all therapies aimed at alleviation of this process have relied on inhibition of VEGF-A activity. Although effective in preventing vascular leak and edema, this approach also leads to the loss of normal vasculature and multiple related side effects.
View Article and Find Full Text PDFTransl Vis Sci Technol
January 2025
FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Purpose: Geographic atrophy (GA), an advanced form of dry age-related macular degeneration (AMD), has limited treatment options. This study introduces a novel mouse model featuring an expanding GA patch that can be used to test mechanisms and therapeutics.
Methods: C57Bl/6J male mice (n = 96) aged 9-10 weeks received an intraperitoneal (IP) injection of 20 mg/kg sodium iodate (NaIO3).
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