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Cardiac Gene Expression Knockdown Using Small Inhibitory RNA-Loaded Microbubbles and Ultrasound.
PLoS One
August 2017
Dept. of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.
RNA interference has potential therapeutic value for cardiac disease, but targeted delivery of interfering RNA is a challenge. Custom designed microbubbles, in conjunction with ultrasound, can deliver small inhibitory RNA to target tissues in vivo. The efficacy of cardiac RNA interference using a microbubble-ultrasound theranostic platform has not been demonstrated in vivo.
View Article and Find Full Text PDFTherapeutic ultrasound: Increased HDL-Cholesterol following infusions of acoustic microspheres and apolipoprotein A-I plasmids.
Atherosclerosis
July 2015
Sulpizio Cardiovascular Center, University of California, San Diego, CA, USA.
Background: Low levels of HDL-C are an independent cardiovascular risk factor associated with increased premature cardiovascular death. However, HDL-C therapies historically have been limited by issues relating to immunogenicity, hepatotoxicity and scalability, and have been ineffective in clinical trials.
Objective: We examined the feasibility of using injectable acoustic microspheres to locally deliver human ApoA-I DNA plasmids in a pre-clinical model and quantify increased production of HDL-C in vivo.
Assessment of microcirculation by contrast-enhanced ultrasound: a new approach in vascular medicine.
Swiss Med Wkly
September 2015
Department of Internal Medicine, Division of Angiology, University Hospital, Basel, Switzerland.
Contrast-enhanced ultrasound (CEUS) has emerged as a valuable imaging modality that complements and enhances standard vascular ultrasound imaging. Ultrasound contrast agents are gas-filled microbubbles that are injected intravenously and serve as intravascular tracers. Based on the properties to enhance and to quantify the macro- and microcirculation down to the capillary perfusion level in different vascular territories and organs, CEUS imaging has the potential to improve the diagnostic performance in the detection and characterisation of various vascular disorders reviewed in this article.
View Article and Find Full Text PDFUltrasound-directed, site-specific gene delivery.
Methods Mol Biol
May 2015
GE Global Research Niskayuna, Schenectady, NY, USA.
With the implementation of gene therapy looming in the near term, an effective delivery system using noninvasive, nonviral-mediated methods appears as an attractive option. This novel platform technology uses gas-filled, ultrasound-directed acoustic microspheres for both diagnostic imaging and therapy and yet may provide a key component for future success in the pursuit of single-gene replacement therapy.
View Article and Find Full Text PDFIntravenous ultrasound-directed superior vena cava filter placement without contrast.
Am Surg
September 2012
Department of Surgery, Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.
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