We performed method comparison for the tumor markers CA 15-3, CA 19-9, and CA 125 measured by luminescent oxygen channeling immunoassay technology on the Dimension Vista 1500 and by classic luminescence technology on the Immulite 2000 XPI. Within-day and total imprecision were determined according to Clinical and Laboratory Standards Institute (CLSI) guidelines using three serum pools at different clinically relevant levels. In addition, parallel measurements on both systems were performed in a total of 738 routine serum samples (133 CA 15-3, 395 CA 19-9, and 210 CA 125). Total imprecision of serum pools for CA 15-3 ranged between 4.6% and 5.9%, for CA 19-9 between 4.4% and 7.8%, and for CA 125 between 3.3% and 4.3%. Marker values determined within the measurement range of both systems correlated well with each other (R = 0.88 for CA 15-3, R = 0.93 for CA 19-9, and R = 0.96 for CA 125). Slopes between the Vista and the Immulite method were 0.96 for CA 125, 0.72 for CA 15-3, and 0.87 for CA 19-9, indicating lower values for CA 15-3 and CA 19-9 when measured by the Vista method. This was particularly obvious for CA 19-9 levels in the lower measuring range of <100 U/mL (R = 0.85; slope 0.73).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/15321819.2012.666221 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Real-world effectiveness and safety of second- or third-line pegylated liposomal irinotecan plus 5-fluorouracil and folinic acid in pancreatic ductal adenocarcinoma in Spain.
Ther Adv Med Oncol
January 2025
Centro Integral Oncológico Clara Campal HM CIOCC, Hospital Universitario HM Sanchinarro, Madrid, Spain.
Treatment with pegylated nanoliposomal irinotecan (nal-IRI) plus 5-fluorouracil/leucovorin (folinic acid; 5-FU/LV) has demonstrated remarkable efficacy for metastatic pancreatic ductal adenocarcinoma (PDAC) in clinical trials. However, real-world data on the effectiveness of nal-IRI+5-FU/LV is heterogeneous and is lacking in Spain. To assess the effectiveness and safety of nal-IRI+5-FU/LV in real-life PDAC patients in Spain.
View Article and Find Full Text PDFCourse of Mental Disorders in Early Cancer Survivorship in Relation to Socioeconomic Status: A Multi-Center Prospective Longitudinal Study (LUPE).
Psychooncology
January 2025
Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Leipzig, Germany.
Objective: Individuals with low socioeconomic status (SES) exhibit higher rates of mental disorders; however, data in oncological populations are insufficient. This study investigated the course of DSM-5 mental disorders in cancer patients, stratified by SES, over a period of 1.5 years following initial cancer diagnosis.
View Article and Find Full Text PDFFracture incidence in women: the impact of reproductive characteristics.
BMC Public Health
December 2024
Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 24 Parvaneh St., Yaman St., Velenjak, PO Box 19395-4763, Tehran, Iran.
Article Synopsis
- The study investigates how reproductive factors (RFs) like age at menarche, number of births, and duration of breastfeeding affect the risk of fractures in women.
- It followed a cohort of women from 1999 to 2021, finding that 3.3% experienced fractures during the study period, while adjusting for confounders.
- Results indicated that more childbirths and older age at menarche increase fracture risk, while longer exclusive breastfeeding decreases it.
The Impact of Artificial Intelligence on Radiologists' Reading Time in Bone Age Radiograph Assessment: A Preliminary Retrospective Observational Study.
J Imaging Inform Med
November 2024
Department of Radiology, Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, 16995, Yongin-si, Gyeonggi-do, Republic of Korea.
To evaluate the real-world impact of artificial intelligence (AI) on radiologists' reading time during bone age (BA) radiograph assessments. Patients (<19 year-old) who underwent left-hand BA radiographs between December 2021 and October 2023 were retrospectively included. A commercial AI software was installed from October 2022.
View Article and Find Full Text PDFFinal diagnoses and mortality rates in ambulance patients administered nebulized β2-agonists bronchodilators.
Intern Emerg Med
November 2024
Department of Research & Development, Prehospital Emergency Medical Services, Central Denmark Region, Aarhus, Denmark.
Article Synopsis
- The study analyzes the final diagnoses and mortality rates (30-day and 1-year) in patients treated with salbutamol by ambulance personnel for respiratory distress in Central Denmark (2018-2019).
- It includes 6,318 ambulance transports, highlighting conditions such as acute exacerbation of chronic obstructive pulmonary disease (AECOPD), community-acquired pneumonia (CAP), and asthma, with differing mortality rates across these groups.
- The findings emphasize high mortality rates among those needing bronchodilator treatment, particularly in AECOPD and heart disease patients, while asthma patients and those under 18 show lower mortality, suggesting the use of inhaled bronchodilators as an important indicator of serious respiratory distress requiring prompt action.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!