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Source attribution of Listeria monocytogenes in the Netherlands.
Int J Food Microbiol
January 2025
Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands.
Article Synopsis
- The study aimed to find out which food sources contribute to human listeriosis and the specific risk factors associated with those sources, using data from the Netherlands between 2010-2020.
- It involved whole genome sequencing of Listeria monocytogenes (Lm) isolates from 756 human cases and 950 food/animal sources, along with exposure data from questionnaires.
- The results showed that cattle were the primary source of infection (62.3%), especially fresh beef, while other sources included chicken (19.4%) and seafood (16.9%), with specific foods like steak tartare and smoked salmon linked to higher infection risks.
We traced back a nationwide outbreak of human listeriosis in Switzerland to a persisting production line contamination of a factory producing baker's yeast with Listeria monocytogenes serotype 1/2a sequence type 3141. We used whole-genome sequencing to match clinical isolates to isolates from product samples.
View Article and Find Full Text PDFC metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8 T cells.
Sci Adv
May 2024
Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Infusion of C-labeled metabolites provides a gold standard for understanding the metabolic processes used by T cells during immune responses in vivo. Through infusion of C-labeled metabolites (glucose, glutamine, and acetate) in -infected mice, we demonstrate that CD8 T effector (Teff) cells use metabolites for specific pathways during specific phases of activation. Highly proliferative early Teff cells in vivo shunt glucose primarily toward nucleotide synthesis and leverage glutamine anaplerosis in the tricarboxylic acid (TCA) cycle to support adenosine triphosphate and de novo pyrimidine synthesis.
View Article and Find Full Text PDFUnveiling the Mutations and Conservation of InlA in .
Microorganisms
February 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
() is a pathogen that is transmitted through contaminated food and causes the illness known as listeriosis. The virulence factor InlA plays a crucial role in the invasion of into the human intestinal epithelium. In addition, InlA enhances the pathogenicity of host strains, and different strains of contain varying variations of InlA.
View Article and Find Full Text PDFTracking the contamination sources of microbial population and characterizing in a chicken slaughterhouse by using culture-dependent and -independent methods.
Front Microbiol
November 2023
College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea.
Article Synopsis
- - Listeria monocytogenes is a harmful bacteria causing listeriosis, particularly found on chicken meat, which can easily become contaminated during butchery.
- - This study investigated contamination sources and routes at an abattoir that tested positive for Listeria over three years (2019-2021), using both culture-dependent and culture-independent methods for thorough analysis.
- - Findings showed that contamination predominantly occurred in the clean zone of the slaughterhouse, with significant links to chilling water and shackles, and culture-independent methods like qPCR provided better insight into contamination points than traditional methods.
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