Aspergillus oryzae has an ortholog of Saccharomyces cerevisiae KEX1, termed kexA. A truncated form of KexA protein showed serine-type carboxypeptidase activity and somewhat broader substrate specificity than Kex1 protease. Furthermore, our results indicated that KexA is required for normal growth of A. oryzae and that it might be involved in hyphal branching.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485961 | PMC |
| http://dx.doi.org/10.1128/AEM.01601-12 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High-level ceftriaxone resistance due to transfer of penA allele 60.001 into endemic gonococcal lineages in Hangzhou, China.
J Antimicrob Chemother
November 2024
Department of Microbiology, and Department of Dermatology of Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Article Synopsis
- The study examines the prevalence and resistance of Neisseria gonorrhoeae strains in Hangzhou, China, focusing on the high-level ceftriaxone-resistant FC428 clone and its resistance determinant, penA allele 60.001, from 2020 to 2022.
- Out of 209 gonococcal isolates tested, 16% showed resistance to ceftriaxone, with 6.7% exhibiting high-level resistance, particularly in isolates containing penA allele 60.001.
- The findings highlight ongoing transmission of resistant strains and raise public health concerns regarding the spread of the resistance trait among local endemic lineages.
Targeting AGTPBP1 inhibits pancreatic cancer progression via regulating microtubules and ERK signaling pathway.
Mol Med
August 2024
Department of Hepatobiliary, Pancreatic and Splenic Surgery, The Affiliated Hospital of Inner Mongolia Medical University, #1, Tongdao North Street, Huhhot, 010051, PR China.
Article Synopsis
- AGTPBP1 is a carboxypeptidase involved in cleaving poly-glutamic acids from tubulins and has been linked to non-small cell lung cancer, but its role in pancreatic cancer (PC) remains unclear.
- The study used immunohistochemistry to analyze AGTPBP1 expression in PC and non-cancerous tissues, and employed siRNA to knock down AGTPBP1 in PC cells to observe effects on cancer cell behavior.
- Results showed that AGTPBP1 is overexpressed in PC, and its inhibition reduces cell progression and affects several proteins in the ERK signaling pathway, suggesting it could be a potential therapeutic target for pancreatic cancer.
Receptors Involved in COVID-19-Related Anosmia: An Update on the Pathophysiology and the Mechanistic Aspects.
Int J Mol Sci
August 2024
Department of Biological Sciences, School of Science, The University of Jordan, Amman 11942, Jordan.
Olfactory perception is an important physiological function for human well-being and health. Loss of olfaction, or anosmia, caused by viral infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has received considerable attention, especially in persistent cases that take a long time to recover. This review discusses the integration of different components of the olfactory epithelium to serve as a structural and functional unit and explores how they are affected during viral infections, leading to the development of olfactory dysfunction.
View Article and Find Full Text PDFMolecular Basis of Influence of A501X Mutations in Penicillin-Binding Protein 2 of Strain 35/02 on Ceftriaxone Resistance.
Int J Mol Sci
July 2024
Bach Institute of Biochemistry, Federal Research Centre "Fundamentals of Biotechnology", Russian Academy of Sciences, 119071 Moscow, Russia.
The increase in the resistance of mutant strains of to the antibiotic ceftriaxone is pronounced in the decrease in the second-order acylation rate constant, k/K, by penicillin-binding protein 2 (PBP2). These changes can be caused by both the decrease in the acylation rate constant, k, and the weakening of the binding affinity, i.e.
View Article and Find Full Text PDFAntibody-assisted selective isolation of Purkinje cell nuclei from mouse cerebellar tissue.
Cell Rep Methods
July 2024
Department of Neuronal Cell Biology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland. Electronic address:
We developed a method that utilizes fluorescent labeling of nuclear envelopes alongside cytometry sorting for the selective isolation of Purkinje cell (PC) nuclei. Beginning with SUN1 reporter mice, we GFP-tagged envelopes to confirm that PC nuclei could be accurately separated from other cell types. We then developed an antibody-based protocol to make PC nuclear isolation more robust and adaptable to cerebellar tissues of any genotypic background.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!