AI Article Synopsis
- Malignant mesothelioma (MM) is a rare and aggressive cancer, particularly uncommon in children, and this case report describes a 7-year-old boy without a history of asbestos exposure who developed peritoneal MM.
- Initially, his cancer responded well to chemotherapy with cisplatin and gemcitabine, but it later spread to his chest, highlighting the aggressive nature of the disease.
- Diagnosis was confirmed through histology, immunohistochemical analyses, and elevated serum CA-125 levels, while genetic testing revealed an extra copy of chromosome 11 with minimal other changes.
Article Abstract
Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was diagnosed with MM based on histology, extensive immunohistochemical analyses, and an elevated serum CA-125 level. Cytogenetics and comparative genomic hybridization (CGH) analysis of his tumor identified a single extra copy number of chromosome 11 with few other changes noted.
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| http://dx.doi.org/10.1002/pbc.24284 | DOI Listing |
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