From A to B: Through detailed biochemical investigations, we discovered that VldW, an α-ketoglutarate/Fe(II)-dependent dioxygenase, regioselectively hydroxylates validamycin A to validamycin B. The results provide insights into the biosynthesis of hydroxylated validamycins and could be used to control the metabolic outcomes of the validamycin pathway.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517013 | PMC |
| http://dx.doi.org/10.1002/cbic.201200464 | DOI Listing |
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