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Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats. | LitMetric

AI Article Synopsis

  • - The root of Plumbago zeylanica L. has traditional uses in Indian medicine for managing diabetes, and this study aimed to analyze the antidiabetic effects of an active compound called plumbagin.
  • - Diabetic rats were treated with plumbagin for 28 days, demonstrating significant reductions in blood glucose levels and improvements in various biochemical parameters related to diabetes.
  • - Treatment with plumbagin increased the expression of GLUT4, a protein responsible for glucose uptake in muscles, suggesting its potential as a therapeutic option for diabetes management.

Article Abstract

Plumbago zeylanica L. root is widely used in Indian medicine to treat diabetes mellitus. The aim of the present investigation was to evaluate the antidiabetic effects of plumbagin isolated from P. zeylanica L. root and its effect on GLUT4 translocation in STZ-induced diabetic rats. Plumbagin (15 and 30 mg/kg b wt) was orally administered to STZ-induced diabetic rats for 28 days. An oral glucose tolerance test was performed on 21st day. The effect of plumbagin on body weight, blood glucose, plasma insulin, total protein, urea, creatinine, liver glycogen, plasma enzymes (SGOT, SGPT and ALP) and carbohydrate metabolism enzymes (glucose-6-phosphatase, fructose-1,6-bisphosphatase and hexokinase) were investigated. GLUT4 mRNA and protein expression in skeletal muscles were also studied. Plumbagin significantly reduced the blood glucose and significantly altered all other biochemical parameters to near normal. Further, plumbagin increased the activity of hexokinase and decreased the activities of glucose-6-phosphatase and fructose-1,6-bisphosphatase significantly in treated diabetic rats. Enhanced GLUT4 mRNA and protein expression were observed in diabetic rats after treatment with plumbagin. The results indicated that plumbagin enhanced GLUT4 translocation and contributed to glucose homeostasis. It could be further probed for use as a drug to treat diabetes.

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Source
http://dx.doi.org/10.1016/j.fct.2012.08.046DOI Listing

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