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Although the areal Bone Mineral Density (BMD) measurements from dual-energy X-ray absorptiometry (DXA) are able to discriminate between hip fracture cases and controls, the femoral strength is largely determined by the 3D bone structure. In a previous work a statistical model was presented which parameterizes the 3D shape and BMD distribution of the proximal femur. In this study the parameter values resulting from the registration of the model onto DXA images are evaluated for their hip fracture discrimination ability with respect to regular DXA derived areal BMD measurements. The statistical model was constructed from a large database of QCT scans of females with an average age of 67.8 ± 17.0 years. This model was subsequently registered onto the DXA images of a fracture and control group. The fracture group consisted of 175 female patients with an average age of 66.4 ± 9.9 years who suffered a fracture on the contra lateral femur. The control group consisted of 175 female subjects with an average age of 65.3 ± 10.0 years and no fracture history. The discrimination ability of the resulting model parameter values, as well as the areal BMD measurements extracted from the DXA images were evaluated using a logistic regression analysis. The area under the receiver operating curve (AUC) of the combined model parameters and areal BMD values was 0.840 (95% CI 0.799-0.881), whilst using only the areal BMD values resulted in an AUC of 0.802 (95% CI 0.757-0.848). These results indicate that the discrimination ability of the areal BMD values is improved by supplementing them with the model parameter values, which give a more complete representation of the subject specific shape and internal bone distribution. Thus, the presented method potentially allows for an improved hip fracture risk estimation whilst maintaining DXA as the current standard modality.
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http://dx.doi.org/10.1016/j.bone.2012.08.114 | DOI Listing |
Front Pediatr
December 2024
Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Introduction: Osteogenesis imperfecta (OI) is a congenital skeletal disorder characterized by bone fragility. Bisphosphonates (BISs) have become the mainstream treatment in children with OI. However, an optimal treatment protocol has not yet been established, while BIS treatment tends to be administered to normalize bone mineral density (BMD).
View Article and Find Full Text PDFBone Rep
September 2024
ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland.
Aging is associated with an increased risk of fragility fractures at the hip, resulting from a loss of bone mass. While this loss is typically reported as a decreased mean areal bone mineral density (aBMD) in the proximal femur or the femoral neck, its evolution is spatially inhomogeneous, which might also contribute to the increased risk of fractures. Yet, little is known about the evolution of BMD distribution and cortical thickness with age in the proximal femur.
View Article and Find Full Text PDFJ Spinal Cord Med
December 2024
Department of Physical Medicine and Rehabilitation, National Rehabilitation Center, Seoul, Republic of Korea.
To identify the prevalence and risk factors for low bone density (LBD) in young adults with spinal cord injury (SCI). Retrospective cross-sectional study. National Rehabilitation Center in Seoul, Korea.
View Article and Find Full Text PDFJBMR Plus
December 2024
Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Lottestrasse 59, 22529 Hamburg, Germany.
Int J Sports Physiol Perform
December 2024
Centre for Healthy Youth Development Through Sport, Department of Kinesiology, Brock University, St Catharines, ON, Canada.
Purpose: Bone mineral measurements and their association with peak impact and sport-specific, persistent muscle loads were examined in 10 elite artistic swimmers age 15-19 years.
Methods: Bone mineral density (BMD) and bone mineral content (BMC) of total body, total body less head, spine, and dominant and nondominant limbs were assessed by dual-energy X-ray absorptiometry. Peak ground-reaction forces of 2 dry jumps (countermovement jump and frog jump) were measured on a force plate.
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