AI Article Synopsis
- The study examines the role of podocyte intercellular junction proteins in glomerular diseases, highlighting their importance for forming and maintaining cell junctions.
- Deleting these proteins can lead to foot process effacement and proteinuria, indicating their critical function in kidney health.
- The review emphasizes how the nephrin-neph1-podocin-receptor complex influences cytoskeletal dynamics, affecting the structure and repair of intercellular junctions in response to injury.
Article Abstract
Observations of hereditary glomerular disease support the contention that podocyte intercellular junction proteins are essential for junction formation and maintenance. Genetic deletion of most of these podocyte intercellular junction proteins results in foot process effacement and proteinuria. This review focuses on the current understanding of molecular mechanisms by which podocyte intercellular junction proteins such as the nephrin-neph1-podocin-receptor complex coordinate cytoskeletal dynamics and thus intercellular junction formation, maintenance, and injury-dependent remodeling.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438455 | PMC |
| http://dx.doi.org/10.1016/j.semnephrol.2012.06.002 | DOI Listing |
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