Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415118 | PMC |
| http://dx.doi.org/10.1186/2049-6958-7-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impaired postprandial GLP-2 response enhances endotoxemia, systemic inflammation, and kidney injury in metabolic dysfunction-associated steatohepatitis (MASH): effect of phospholipid curcumin meriva.
Gut Microbes
December 2024
Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
We investigate the role of homeostatic mechanisms involved in acute, postprandial nutrient metabolism and nutrient-induced systemic inflammation in CKD presence and progression in Metabolic dysfunction-associated steatohepatitis (MASH). We assessed postprandial incretins (GLP-1 and GIP), intestinotropic hormone GLP-2, endotoxin LPS, Zonulin (a marker of intestinal permeability), hepatokines, adipokines and NF-kB activation in circulating MNCs during a meal tolerance test in 52 biopsy proven MASH patients randomized to curcumin Meriva or placebo and 26 matched controls. At baseline, MASH-CKD had a lower GLP-2 response and a 2-fold higher postprandial LPS and NF-kB activation in MNCs than MASH patients without CKD, but similar remaining postprandial or fasting parameters.
View Article and Find Full Text PDFImpact of Fluid Balance on the Development of Lung Injury.
Am J Respir Crit Care Med
November 2024
University Medical Center Göttingen, Department of Anesthesiology, University Medical Center Göttingen, Robert-Koch-Str 40, 37075, Gottingen, Germany.
Rationale: The pathophysiological relationship between fluid administration, fluid balance, and mechanical ventilation in the development of lung injury is unclear.
Objectives: To quantify the relative contribution of mechanical power and fluid balance in the development of lung injury.
Methods: Thirty-nine healthy female pigs, divided into four groups, were ventilated for 48 hours with high (~18J/min) or low (~6J/min) mechanical power; and high (~4L) or low (~1L) targeted fluid balance.
Advancing titanium dioxide coated photocatalytic depolluting surfaces: Leveraging ASINA's roadmap for safer and sustainable solutions.
Comput Struct Biotechnol J
December 2024
CNR-ISSMC Istituto di Scienza e Tecnologia dei Materiali Ceramici, Via Granarolo, 64, Faenza, RA 48018, Italy.
This report, the second of its kind from ASINA project, aims at providing a roadmap with quantitative metrics for Safe(r) and (more) Sustainable by Design (SSbD) solutions for titanium dioxide (TiO) nanomaterials (NMs). We begin with a brief description of ASINA's methodology across the product lifecycle, highlighting the quantitative elements, such as the Key Performance Indicators (KPIs). We then propose a decision support tool for implementing SSbD objectives across various dimensions-functionality, cost, environment, and human health safety.
View Article and Find Full Text PDFFIT as a Comparator for Evaluating the Effectiveness of New Non-invasive CRC Screening Test.
Dig Dis Sci
November 2024
CHU Caen Normandie, INSERM ANTICIPE U1086, Université Caen Normandie, 14000, Caen, France.
Randomized Controlled Trials (RCT) demonstrated that guaiac-based fecal occult blood test (gFOBT), sigmoidoscopy, or colonoscopy are effective at reducing colorectal cancer (CRC) risk and mortality. Even if the impact of fecal immunochemical test (FIT) has not been evaluated within population-based RCT with mortality as the outcome, the results of comparative analyses with gFOBT provide strong indirect evidence of its effectiveness. Extensive information is also available on sensitivity and specificity of FIT, compared with gFOBT.
View Article and Find Full Text PDFFecal Immunochemical Test Positivity Thresholds: An International Survey of Population-Based Screening Programs.
Dig Dis Sci
November 2024
Flinders University, Adelaide, SA, Australia.
Background: The fecal immunochemical test for hemoglobin (FIT) is now a widely used non-invasive test in population-based organized screening programs for colorectal neoplasia. The positivity thresholds of tests currently in use are based on the fecal hemoglobin concentration (f-Hb), but the rationale for the adopted thresholds are not well documented. To understand current global usage of FIT in screening programs we conducted an international survey of the brands of FIT used, the f-Hb positivity threshold applied and the rationale for the choice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!