One-hundred-and-twenty-eight-section dual X-ray source computed tomography (CT) systems have been introduced into clinical practice and have been shown to increase temporal resolution. Higher temporal resolution allows low-dose spiral mode at a high pitch factor during CT coronary angiography. We evaluated radiation dose and physical image qualities in CT coronary angiography by applying high-pitch spiral, step-and-shoot, and low-pitch spiral modes to determine the optimal acquisition mode for clinical situations. An anthropomorphic phantom, small dosimeters, a calibration phantom, and a microdisc phantom were used to evaluate the radiation doses absorbed by thoracic organs, noise power spectrums, in-plane and z-axis modulation transfer functions, slice sensitivity profiles, and number of artifacts for the three acquisition modes. The high-pitch spiral mode had the advantage of a small absorbed radiation dose, but provided low image quality. The low-pitch spiral mode resulted in a high absorbed radiation dose of approximately 200 mGy for the heart. Although the absorbed radiation dose was lower in the step-and-shoot mode than in the low-pitch spiral mode, the noise power spectrum was inferior. The quality of the in-plane modulation transfer function differed, depending on spatial frequency. Therefore, the step-and-shoot mode should be applied initially because of its low absorbed radiation dose and superior image quality.
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http://dx.doi.org/10.1120/jacmp.v13i5.3959 | DOI Listing |
Invest Radiol
October 2024
From the Institute for Diagnostic and Interventional Radiology, University Hospital Zurich, University Zurich, Zurich, Switzerland (B.K., F.E., J.K., T.F., L.J.); Advanced Radiology Center, Department of Diagnostic Imaging and Oncological Radiotherapy, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy (C.S., A.R.L.); and Section of Radiology, Department of Radiological and Hematological Sciences, Università Cattolica del Sacro Cuore, Rome, Italy (A.R.L.).
Objectives: The aim of this study was to evaluate the feasibility and efficacy of visual scoring, low-attenuation volume (LAV), and deep learning methods for estimating emphysema extent in x-ray dose photon-counting detector computed tomography (PCD-CT), aiming to explore future dose reduction potentials.
Methods: One hundred one prospectively enrolled patients underwent noncontrast low- and chest x-ray dose CT scans in the same study using PCD-CT. Overall image quality, sharpness, and noise, as well as visual emphysema pattern (no, trace, mild, moderate, confluent, and advanced destructive emphysema; as defined by the Fleischner Society), were independently assessed by 2 experienced radiologists for low- and x-ray dose images, followed by an expert consensus read.
Med Phys
December 2024
Department of Physics, Lakehead University, Thunder Bay, Ontario, Canada.
Background: This study investigates a multi-angle acquisition method aimed at improving image quality in organ-targeted PET detectors with planar detector heads. Organ-targeted PET technologies have emerged to address limitations of conventional whole-body PET/CT systems, such as restricted axial field-of-view (AFOV), limited spatial resolution, and high radiation exposure associated with PET procedures. The AFOV in organ-targeted PET can be adjusted to the organ of interest, minimizing unwanted signals from other parts of the body, thus improving signal collection efficiency and reducing the dose of administered radiotracer.
View Article and Find Full Text PDFPLoS One
December 2024
Chair of Biomedical Physics, Department of Physics & School of Natural Sciences, Technical University of Munich, Garching bei München, Germany.
Background: Dark-field radiography has been proven to be a promising tool for the assessment of various lung diseases.
Purpose: To evaluate the potential of dose reduction in dark-field chest radiography for the detection of the Coronavirus SARS-CoV-2 (COVID-19) pneumonia.
Materials And Methods: Patients aged at least 18 years with a medically indicated chest computed tomography scan (CT scan) were screened for participation in a prospective study between October 2018 and December 2020.
J Palliat Med
December 2024
Department of Radiation Oncology, Saitama Medical center, Saitama, Japan.
Utility values of responders and nonresponders are essential inputs in cost-effectiveness studies of radiation therapy for painful bone metastases but, to our knowledge, they have not been reported separately. We sought to determine the utility values of responders and nonresponders using data from a prospective observational study on bone metastases. The original prospective observational study was conducted at 26 centers in Japan.
View Article and Find Full Text PDFEJNMMI Res
December 2024
μNEURO Research Centre of Excellence, Universiteitsplein 1, University of Antwerp, Antwerp, Belgium.
Background: Huntington's disease (HD) is a rare neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the huntingtin gene which encodes the mutant huntingtin protein (mHTT) that is associated with HD-related neuropathophysiology. Noninvasive visualization of mHTT aggregates in the brain, with positron emission tomography (PET), will allow to reliably evaluate the efficacy of therapeutic interventions in HD. This study aimed to assess the radiation burden of [F]CHDI-650, a novel fluorinated mHTT radioligand, in humans based on both in vivo and ex vivo biodistribution in mice and subsequent determination of dosimetry for dosing in humans.
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