Background: Patients with rheumatoid arthritis (RA) in the United Arab Emirates (UAE) have previously been found to have a long delay to diagnosis and low utilization of disease-modifying antirheumatic drugs (DMARDs). Over the past 5 years, support groups, awareness programs, and public campaigns have been instituted in the region.
Aim: This study aimed to assess whether such initiatives have affected the lag to diagnosis previously observed.
Methods: Demographic, disease, and treatment data on the first 100 patients meeting American College of Rheumatology (1987) criteria for RA, presenting to our practice for the first time, were compared with similar data from 2006 on patients presenting to a different musculoskeletal clinic.
Results: Subjects had a mean age of 40.2 (±11.0) years (42.2 [±12.3] years in the previous study; Student t test, P > 0.05). Rheumatoid factor was positive in 62% of subjects, whereas 73% were titer positive in the previous study (χ(2) test, P > 0.05). There was a mean reduction in lag time from symptom onset to diagnosis by 45.8%, from 14.4 (±15.6) to 7.8 (±12.1) months (Student t test, P = 0.001) between data sets. The lag to initial DMARD was also reduced by a mean of 34.9%, from 19.2 (±24) to 12.5 (±21.7) months (Student t test, P = 0.04).
Conclusions: Findings suggest that the lag to diagnosis and initiation of DMARD therapy has reduced significantly among patients with RA in the United Arab Emirates, over the past 5 years. This may be attributed to the inception of patient support groups and increasing public awareness. Larger studies are needed to substantiate this further and to address whether shorter lag times can positively influence rates of disease remission and quality of life for our patients with RA (as this was a region specific study).
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http://dx.doi.org/10.1097/RHU.0b013e3182676975 | DOI Listing |
Alzheimers Dement
December 2024
Instituto Peruano de Neurociencias, Lima, Lima, Peru.
Background: Dementia is considered a public health problem due to the exponential increase in cases in recent years, as it not only has an impact on health services, but also affects the social and economic level, especially in low and middle income countries. Evidence has shown that a trained caregiver improves the patient's quality of life, reduces behavioural symptoms and decreases the likelihood of the caregiver developing burnout. Currently scarce research has reported on the level of knowledge of dementia, specifically targeting caregivers in LMIC, that's why we aimed to measure the level of knowledge of caregivers attending to monthly training compared to untrained caregivers.
View Article and Find Full Text PDFCurr Opin Gastroenterol
January 2025
Assistant Professor of Neonatal-Perinatal Medicine, Department of Pediatrics, School of Medicine, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
Purpose Of Review: Whether low birth weight (LBW) and preterm delivery (PD) are associated with the risk of developing celiac disease (CD) in children remains unclear. This systematic review and meta-analysis aimed to evaluate the association between LBW and PD with CD development in children.
Recent Findings: We searched PubMed, Embase, Scopus, Web of Science, and Google Scholar databases based on the Mesh terms to find observational studies that investigated the association of LBW and PD with CD development in children up to July 18, 2024.
Alzheimers Dement
December 2024
University of Minnesota Duluth, Duluth, MN, USA.
Background: When designing cutting-edge technology, particularly humanoid social robots, an essential consideration is understanding how individuals naturally engage in social interactions, shaping their relationships with technology and media.
Method: In pursuit of insights into the application of natural human behavior, specifically reciprocation, in human-robot interaction, an experiment involving 72 participants, involving facial electromyography, focusing on zygomatic and corrugator muscles, served as a tool to gauge users' emotional valence during interactions. The study assessed users' willingness to reciprocate a favor and measured compliance by tracking the number of raffle tickets purchased by users at the robot's request.
Alzheimers Dement
December 2024
Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE), site Rostock / Greifswald, Rostock, Germany.
Background: Familial Alzheimer's disease research necessitates innovative methodologies to disentangle the intricate relationships between genetic factors and neuroimaging measures. Traditional frequentist approaches, often hampered by small sample sizes in this population and challenges in incorporating prior knowledge transparently, may limit the robustness of findings.
Methods: We analyzed neuroimaging data of preclinical PSNE1 single mutation carriers, utilizing the software JASP to test effects of carrier status on measures of basal forebrain functional connectivity using both frequentist and Bayesian approach.
J Magn Reson Imaging
January 2025
High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.
Background: Pancreatic damage is a common digestive system disease with no specific drugs. Static magnetic field (SMF), the key component of magnetic resonance imaging (MRI), has demonstrated prominent effects in various disease models.
Purpose: To study the effects of 0.
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