AI Article Synopsis
- Telaprevir is an HCV NS3/4A protease inhibitor that significantly improves treatment outcomes when combined with pegylated interferon and ribavirin.
- It has good oral absorption, especially when taken with food, and is mainly cleared from the body through feces.
- Telaprevir does not require dose adjustments for patients with certain levels of renal or liver impairment but can interact with other drugs due to its role as a substrate and inhibitor of cytochrome P450 3A and P-glycoprotein.
Article Abstract
Telaprevir is an inhibitor of the HCV NS3/4A protease. When used in combination with pegylated interferon and ribavirin, telaprevir has demonstrated a substantial increase in sustained virological response compared with pegylated interferon and ribavirin used alone. Telaprevir has good oral bioavailability, which is enhanced when administered with food. Telaprevir is extensively metabolized and primarily eliminated via faeces. No dose adjustment of telaprevir is needed in patients with mild to severe renal impairment or mild liver impairment. Telaprevir is a substrate and inhibitor of cytochrome P450 3A and P-glycoprotein and, thus, might interact with coadministered drugs that affect or are affected by these metabolic/transport pathways. This article reviews the pharmacokinetic and drug interaction profile of telaprevir.
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