AI Article Synopsis
Article Abstract
Background: Spitzoid malignant melanoma (SMM) shares many histopathologic features with Spitz nevus (SN). The distinction between SMM and SN remains one of the most difficult diagnostic problems in dermatopathology. Neuropilin-2 (NRP2) is a cytoplasmic/cell surface protein that is a mediator of melanoma-endothelial cell interaction.
Objective: The aim of this study was to evaluate NRP2 expression in SMM and SN and to determine whether it can reliably differentiate between the 2 groups.
Methods: We studied the expression of NRP2 in 19 cases of SMM and 19 cases of SN from Yale Spitzoid Neoplasm Repository, New Haven, Conn.
Results: All 19 cases of SMM (100%) expressed NRP2. Most SMM showed moderate- and high-intensity staining in the majority of the melanoma cells. Most of the SN (14/19, 74%) were negative for the marker. NRP2 labeled only 5 of 19 SN (26%) and all of them demonstrated mild staining intensity. NRP2(+) staining was statistically significant in differentiating SMM from SN (P < .05).
Limitations: Small study size is a limitation.
Conclusions: NRP2 expression in SMM and SN may be a useful adjunct marker, in addition to histopathologic evaluation, in the differentiation between these 2 entities.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jaad.2012.07.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Role of Targeted Sequencing in Routine Diagnostics of Spitz Melanocytic Neoplasms-An Analysis of 70 Cases.
J Cutan Pathol
February 2025
Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Article Synopsis
- The Spitz group of melanocytic tumors should ideally include those with specific genomic changes like kinase receptor fusions and HRAS mutations, while traditional melanoma markers like BRAF mutations indicate a different diagnosis.
- A study involving 70 melanocytic tumors utilized targeted sequencing to differentiate between Spitz and conventional melanomas and clarify their classifications.
- The findings revealed substantial discrepancies in initial diagnoses, with 34% of cases having differing outcomes after molecular analysis, highlighting the need for genetic testing to improve diagnostic reliability in challenging cases.
Spitz melanoma.
Clin Dermatol
September 2024
Departments of Pathology and Dermatology, UCSF Dermatopathology and Oral Pathology Service, University of California at San Francisco School of Medicine, San Francisco, California, USA. Electronic address:
Article Synopsis
- - The distinction between Spitz nevus and melanoma can be challenging due to their similar histopathologic features, such as large melanocytes with distinct cytoplasm and nuclei.
- - Advances in genomic studies have revealed that Spitz tumors have various genetic origins, leading to different categories of lesions (benign, intermediate, malignant), while some melanomas may resemble Spitz tumors but have typical initiating mutations.
- - The current WHO definition of Spitz tumors focuses on those with mutations in the MAP kinase pathway, aiming to clarify classification and guide treatment, especially for tumors prevalent in younger individuals.*
Spitzoid melanoma of the finger: a case report.
J Med Case Rep
September 2024
Orthopedic Surgery and Traymatology, Habib Bourguiba Hospital, Sfax, Tunisia.
Background: Melanoma is the most malignant skin tumor, with a high metastatic potential. Spitzoid melanoma is a subtype of melanoma requiring rapid management and extensive tumor resection. We have set the goal to recognize anatomical peculiarities and difficulties diagnoses posed by this type of tumor, as well as to recognize the management modalities, especially the surgical one, of malignant spitzoid melanoma.
View Article and Find Full Text PDFClinical features and outcomes of paediatric Spitz-type lesions.
J Plast Reconstr Aesthet Surg
October 2024
Plastic Surgery Unit, Addenbrooke's Hospital, Hills Rd, Cambridge, UK.
Article Synopsis
- Some doctors in the UK are careful about treating Spitz-type lesions in kids, often suggesting they should be removed to be safe.
- Researchers studied 91 kids with these lesions and found that most had harmless forms, and many did not need ongoing check-ups after treatment.
- The study showed that these lesions are usually not harmful, so doctors don't think aggressive treatments are needed for most kids with these skin spots.
The Clinical, Morphologic, and Molecular Spectrum of BRAF Fusion Spitz Tumors.
Am J Surg Pathol
August 2024
Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
BRAF fusion Spitz neoplasms along with MAP3K8 fusions are among the subtypes of Spitz most likely to be diagnosed as Spitz melanoma. However, the current literature has only limited amounts of clinical follow-up on these cases. In this study, we share our experience with 39 BRAF fusion Spitz neoplasms and provide the greatest number of cases with available clinical follow-up.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!