An enantioselective synthesis of the CGRP antagonist BMS-846372, amenable to large scale preparation, is presented. This new synthesis showcases a chemo- and enantioselective reduction of a cyclohepta[b]pyridine-5,9-dione as well as a Pd-catalyzed alpha-arylation reaction to form the key carbon-carbon bond and set the absolute and relative stereochemistry.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol302262q | DOI Listing |
Publication Analysis
Top Keywords
enantioselective synthesis
8
synthesis cgrp
8
cgrp antagonist
8
efficient scalable
4
scalable enantioselective
4
antagonist enantioselective
4
antagonist bms-846372
4
bms-846372 amenable
4
amenable large
4
large scale
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!