AI Article Synopsis
- Alport syndrome is a genetic disorder mainly affecting type IV collagen, often resulting in kidney issues like glomerulonephritis and eventual kidney failure.
- A case study of a 34-year-old man with Alport syndrome showed chest pain linked to a dilated aortic root, bicuspid aortic valve, aortic insufficiency, and a small ascending aortic dissection requiring surgery.
- The authors emphasize the importance for healthcare providers to be vigilant about potential aortic problems in Alport syndrome patients who exhibit chest pain symptoms.
Article Abstract
Alport syndrome is an inherited disorder of type IV collagen most commonly leading to glomerulonephritis and kidney failure. Various extrarenal manifestations have been reported, including a spectrum of aortic and aortic valve diseases. We report a case of a 34-year-old man with Alport syndrome presenting with chest pain. Work-up showed a dilated aortic root, bicuspid aortic valve, aortic insufficiency, and small ascending aortic dissection necessitating surgical repair. We provide a review of the literature describing aortic pathology in Alport syndrome and suggest that clinicians caring for patients with Alport syndrome have a high index of suspicion for such entities in patients presenting with symptoms of chest pain.
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| http://dx.doi.org/10.1053/j.ajkd.2012.06.024 | DOI Listing |
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