AI Article Synopsis
- A study examined the effects of ACTH-fragment 4-10 on mental performance and cardiovascular changes compared to a placebo in a double-blind, cross-over design.
- Extraverted subjects showed better performance on mental tasks with less increase in heart rate and blood flow when given the heptapeptide, while introverted subjects performed better under placebo conditions.
- The findings suggest that personality types influence how the heptapeptide affects mental efficiency and related cardiovascular responses.
Article Abstract
The effect of the ACTH-fragment 4--10 (30 mg SC) on a mental performance test and on some concomitant cardiovascular changes was investigated in comparison with a placebo in a double blind cross-over study. The subjects were either mainly extraverted or mainly introverted according to Eysenck's 'Maudsley Personality Inventory'. Under the influence of the heptapeptide extraverted subjects achieved a higher total score in the mental task performance with a smaller increase of forearm blood flow and of heart rate than under the influence of the placebo. In contrast, under the influence of the placebo introverted subjects achieved a higher total score in the mental task performance with a smaller increase of forearm blood flow and of heart rate than under the influence of the ACTH-fragment. Personality, therefore, determines to some degree how this centrally acting heptapeptide influences efficiency in the mental task performance and the concomitant cardiovascular changes.
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| http://dx.doi.org/10.1007/BF00492210 | DOI Listing |
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