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DNA Dendron Tagging as a Universal Way to Deliver Proteins to Cells.
J Am Chem Soc
January 2025
Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
The use of proteins as intracellular probes and therapeutic tools is often limited by poor intracellular delivery. One approach to enabling intracellular protein delivery is to transform proteins into spherical nucleic acid (proSNA) nanoconstructs, with surfaces chemically modified with a dense shell of radially oriented DNA that can engage with cell-surface receptors that facilitate endocytosis. However, proteins often have a limited number of available reactive surface residues for DNA conjugation such that the extent of DNA loading and cellular uptake is restricted.
View Article and Find Full Text PDFUsing ecological momentary assessment to quantify Δ-9-tetrahydrocannabinol and cannabidiol use across different forms of cannabis: Feasibility in a sample of Canadian young adults reporting frequent cannabis use.
Addiction
January 2025
Department of Psychology, York University, Toronto, Canada.
Aims: To establish the feasibility of using ecological momentary assessment (EMA) to estimate total quantities of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) used across different forms of cannabis, and to assess the predictive validity of THC estimates for predicting acute cannabis-related consequences.
Design: 14-day EMA using a smartphone application to assess cannabis use in real time.
Setting: Canada.
Applied Mandibular Osteometry in Young Lambs: Morphometric and Clinical Insights.
Anat Histol Embryol
January 2025
Laboratório de Design Anatômico/LabDA-Departamento de Morfologia, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.
Osteometric studies of the mandible are useful for identifying polymorphisms that are affected by general factors of anatomical variation, such as breed and gender, but age-related changes have not yet been reported in sheep. Our results showed that the morphometric parameters of the mandible were significantly affected by the age of the lambs. However, at 155 days of age, the mandible already presents all the morphological characteristics observed in adult animals.
View Article and Find Full Text PDFInfection control nurse: A scoping review.
J Educ Health Promot
November 2024
Department of Child Health Nursing, Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Infection control is a crucial aspect of healthcare delivery aimed at curtailing the spread of infections within healthcare settings. The role of infection control nurses (ICNs) is reported to have a significant contribution in limiting healthcare-associated infections. Scholarly investigations have explored various domains of ICNs.
View Article and Find Full Text PDFGenotoxicity testing of the anthraquinone dye Alizarin Red S.
Curr Res Toxicol
December 2024
Institute of Nutrition and Food Science, Department of Food Safety, University of Bonn, Germany.
The anthraquinone dye Alizarin Red S (ARS) is used for marking live animals, specifically as a tool for monitoring the stock of the endangered European eel by marking caught fish with ARS before releasing the eels back into the wild. As ARS can be found in recaptured eels even years later, knowledge of potential health hazards of ARS is essential for assessing the food safety of eels marked with ARS. As the compound class of anthraquinones is known for their genotoxic and carcinogenic properties, concerns were raised regarding the food safety of marked eels.
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