Although it is known that there is an association between working hours and occupational accidents, there are only few tools which allow for an assessment of the risk associated with different working time arrangements, none of them validated yet by independent samples. Promising tools like the risk index (RI), assessed via the fatigue and risk index calculator, thus need to be validated. Since analyses on the validity of the RI based on individual data found only moderate associations between the RI and the actual accident risk, the question arises, whether a validation based on grouped data yields more promising results. Thus, the validity of the RI was re-examined, using aggregated data, i.e. pooling several individuals into groups of respondents according to their RI-score and performing calculations on the group level in order to control for individual and random variation. The study sample (n=337) was derived from an Internet survey on working hours and health, which contained information on working hours over four weeks and on the occurrence of an occupational accident during the last 12 months. Two models of aggregation were used: a distribution based and a criterion based classification, resulting in four RI groups each. Accident rates for each group were calculated and compared via χ(2)-analyses and fitting trends to the data. Results show, for both models of aggregation, that the accident rate increased exponentially with an increasing RI. Risk was 3.7 times (distribution based aggregation) and 6.5 times (criterion based aggregation) higher in the highest compared to the lowest RI-groups. The exponential trend explained 92% (distribution based aggregation) and 98% (criterion based aggregation) of the variance, respectively. Analyses for homogeneous subgroups (e.g., service sector, and workers with high workload) showed similar trends. Thus the analyses based on aggregated data indicated a considerable and consistently higher validity of the RI than the earlier analyses based on individual data, irrespective of the model of aggregation. These results are quite promising although further analyses based on larger samples are needed to confirm these findings and in order to further develop the RI or similar indices.
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http://dx.doi.org/10.1016/j.aap.2012.08.014 | DOI Listing |
JMIR Public Health Surveill
January 2025
Monitoring, Evaluation, and Learning Platform USAID, Jakarta, Indonesia.
Background: Indonesia's vast archipelago and substantial population size present unique challenges in addressing its multifaceted HIV epidemic, with 90% of its 514 districts and cities reporting cases. Identifying key populations (KPs) is essential for effectively targeting interventions and allocating resources to address the changing dynamics of the epidemic.
Objective: We examine the 2022 mapping of Indonesia's KPs to develop improved HIV and AIDS interventions.
ACS Appl Bio Mater
January 2025
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.
Cuproptosis exhibits enormous application prospects in treatment. However, cuproptosis-based therapy is impeded by the limited intracellular copper ions, the nonspecific delivery, uncontrollable release, and chelation of endogenous overproduced glutathione (GSH). In this work, an ultrasound-triggered nanosonosensitizer (p-TiO-Cu(I)) was constructed for Cu(I) delivery, on-demand release, GSH consumption, and deeper tissue response.
View Article and Find Full Text PDFLangmuir
January 2025
School of Petrochemical Engineering, Liaoning Petrochemical University, Fushun 113001, P. R. China.
The composition conversion in block copolymer induced by external stimuli such as light and pH is an effective strategy to trigger the disassembly of vesicles experimentally. Based on this strategy, the disassembly behavior of the ABA triblock copolymer vesicle induced by the composition conversion from B block to C block was studied using Monte Carlo simulation. In this study, a part of the B block in the ABA triblock copolymer was converted to the new block C with weaker hydrophobicity, forming the ABCA tetrablock copolymer.
View Article and Find Full Text PDFArterioscler Thromb Vasc Biol
January 2025
Research Center of Clinical Medicine, Affiliated Hospital, Nantong University, China. (X.W., D.L.).
Background: Hyperglycemia is a major contributor to endothelial dysfunction and blood vessel damage, leading to severe diabetic microvascular complications. Despite the growing body of research on the underlying mechanisms of endothelial cell (EC) dysfunction, the available drugs based on current knowledge fall short of effectively alleviating these complications. Therefore, our endeavor to explore novel insights into the cellular and molecular mechanisms of endothelial dysfunction is crucial for the field.
View Article and Find Full Text PDFDisabil Rehabil
January 2025
Courage Kenny Rehabilitation Institute, Allina Health, Minneapolis, MN, USA.
Purpose: This study aimed to explore the narratives of people with acquired brain injury (ABI) who participated in the Unmasking Brain Injury project. Through this inquiry, the multifaceted nature of wellbeing after ABI was described in the narratives, which were characterized by identifying facilitators and barriers to overall wellness.
Methods: A mixed-methods approach was utilized for this study.
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