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Topiramate-valproate-induced hyperammonemic encephalopathy syndrome: case report.
J Child Neurol
February 2005
Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital.
A 15-year-old boy with inverted duplication of chromosome 15 was admitted for acute onset of irritability, increasing sleepiness, and worsening of seizures. He had been on valproate and other anti-convulsants. However, he was found to have hyperammonemia within 2 weeks after the addition of low-dose topiramate to valproate.
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