Suspected anaphylaxis to leuprolide acetate depot in two elf owls (Micrathene whitneyi).

J Zoo Wildl Med

College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.

Published: March 2011

AI Article Synopsis

  • - Two female elf owls were treated with leuprolide acetate injections over several years to prevent egg laying, showing no complications during the treatment.
  • - Both owls died immediately after a subsequent injection, leading to an analysis that found the drug was still highly potent (95.7%).
  • - The cause of death is suspected to be either an immediate allergic reaction or a contaminant, highlighting the need for clinicians to consider the risk of anaphylaxis when using this medication in birds.

Article Abstract

Two adult female elf owls (Micrathene whitneyi) were treated with leuprolide acetate depot injections to prevent egg laying. The birds were treated for several years without complications. Several years into the treatment regimen, both birds died immediately after receiving an injection of leuprolide acetate. Remaining drug was analyzed, revealing 95.7% potency. We suspect that either an immediate Type 1 hypersensitivity reaction occurred or a contaminant was present, resulting in the fatalities of these elf owls. No reports of anaphylaxis to leuprolide acetate in birds were identified in the literature. Clinicians should be aware of the possibility of anaphylaxis when administering this medication to avian patients.

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Source
http://dx.doi.org/10.1638/2010-0145.1DOI Listing

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