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http://dx.doi.org/10.1624/105812499X87240 | DOI Listing |
Pediatr Res
June 2024
Discipline of Paediatrics, Trinity College Dublin, the University of Dublin, Dublin, Ireland.
Background: 'Neonatal encephalopathy' (NE) describes a group of conditions in term infants presenting in the earliest days after birth with disturbed neurological function of cerebral origin. NE is aetiologically heterogenous; one cause is peripartum hypoxic ischaemia. Lack of uniformity in the terminology used to describe NE and its diagnostic criteria creates difficulty in the design and interpretation of research and complicates communication with families.
View Article and Find Full Text PDFNat Commun
January 2024
Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF.
View Article and Find Full Text PDFPediatr Res
December 2023
National Institutes of Health, National Institute of Neurological Diseases and Stroke, Bethesda, MD, USA.
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