AI Article Synopsis
- Dextran is used to create nanofibrous membranes by blending with bioactive agents or biodegradable polymers, making it suitable for biomedical purposes.
- In this study, an antibacterial electrospun scaffold was developed using dextran, polyurethane, and ciprofloxacin, and showed excellent morphology and favorable cell interaction.
- The composite mat demonstrated effective bactericidal properties against various bacteria, suggesting its potential as a biomaterial for wound dressing applications.
Article Abstract
Dextran is a versatile biomacromolecule for preparing electrospun nanofibrous membranes by blending with either water-soluble bioactive agents or hydrophobic biodegradable polymers for biomedical applications. In this study, an antibacterial electrospun scaffold was prepared by electrospinning of a solution composed of dextran, polyurethane (PU) and ciprofloxacin HCl (CipHCl) drug. The obtained nanofiber mats have good morphology. The mats were characterized by various analytical techniques. The interaction parameters between fibroblasts and the PU-dextran and PU-dextran-drug scaffolds such as viability, proliferation, and attachment were investigated. The results indicated that the cells interacted favorably with the scaffolds especially the drug-containing one. Moreover, the composite mat showed good bactericidal activity against both of Gram-positive and Gram-negative bacteria. Overall, our results conclude that the introduced scaffold might be an ideal biomaterial for wound dressing applications.
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| http://dx.doi.org/10.1016/j.carbpol.2012.07.071 | DOI Listing |
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