A procedure for modeling the heart valves is presented. Instead of modeling complete leaflet motion, leaflets are modeled in open and closed configurations. The geometry of each configuration can be defined, for example, from in vivo image data. This method enables significant computational savings compared with complete fluid-structure interaction and contact modeling, while maintaining realistic three-dimensional velocity and pressure distributions near the valve, which is not possible from lumped parameter modeling. Leaflets are modeled as immersed, fixed surfaces over which a resistance to flow is assigned. On the basis of local flow conditions, the resistance values assigned for each configuration are changed to switch the valve between open and closed states. This formulation allows for the pressure to be discontinuous across the valve. To illustrate the versatility of the model, realistic and patient-specific simulations are presented, as well as comparison with complete fluid-structure interaction simulation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cnm.2474 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Non-Canonical TERT Activity Initiates Osteogenesis in Calcific Aortic Valve Disease.
Circ Res
January 2025
Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, PA. (R.A.C., C.C.C., R.W., A.C., C.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J. Brown, C.S.H.).
Background: Calcific aortic valve disease is the pathological remodeling of valve leaflets. The initial steps in valve leaflet osteogenic reprogramming are not fully understood. As TERT (telomerase reverse transcriptase) overexpression primes mesenchymal stem cells to differentiate into osteoblasts, we investigated whether TERT contributes to the osteogenic reprogramming of valve interstitial cells.
View Article and Find Full Text PDFA Roadmap of Responses to Asymmetry Stress in Lipid Membranes.
J Phys Chem B
January 2025
Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg 79104, Germany.
The selective insertion of membrane-impermeant amphiphiles such as detergents, (lipo)peptides, drugs, etc. into the leaflet of a membrane causes an imbalance between the intrinsic areas of the and leaflet, referred to as asymmetry stress or differential stress. The literature provides individual mechanisms of how membranes respond to such stress, which are relevant to membrane remodeling processes and leakage phenomena.
View Article and Find Full Text PDFThe biomechanical effect of the O-A angle on the aortic valve under left ventricular assist device support: a primary fluid-structure interaction study.
J Thorac Dis
December 2024
College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
Background: Left ventricular assist device (LVAD) has been widely used as an alternative treatment for heart failure, however, aortic regurgitation is a common complication in patients with LVAD support. And the O-A angle (the angle between LVAD outflow graft and the aorta) is considered as a vital factor associated with the function of aortic valve. To date, the biomechanical effect of the O-A angle on the aortic valve remains largely unknown.
View Article and Find Full Text PDFHybNet: A hybrid deep models for medicinal plant species identification.
MethodsX
June 2025
Department of Computer Science, School of Computing, Amrita Vishwa Vidyapeetham, Mysuru, India.
Real-time plant species detection plays an important role in fields ranging from medicine to biodiversity conservation. Images captured under unconstrained environments, scale variations, different lighting conditions, leaf orientation, complicated backdrops, and leaflet structure make plant species recognition rigorous and time-consuming. Our study addresses this challenge by introducing three pioneering hybrid models, seamlessly integrating the strengths of convolution neural networks.
View Article and Find Full Text PDFComputational Insights into Membrane Disruption by Cell-Penetrating Peptides.
J Chem Inf Model
January 2025
Unit of Biophysics, Department of Biochemistry and Molecular Biology, Facultat de Medicina, Av. Can Domènech s/n, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Catalonia, Spain.
Cell-penetrating peptides (CPPs) can translocate into cells without inducing cytotoxicity. The internalization process implies several steps at different time scales ranging from microseconds to minutes. We combine adaptive Steered Molecular Dynamics (aSMD) with conventional Molecular Dynamics (cMD) to observe nonequilibrium and equilibrium states to study the early mechanisms of peptide-bilayer interaction leading to CPPs internalization.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!