Oxyma and an oxyma derivative, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate (5b), displayed a remarkable effect on selective esterifications of primary alcohols. A wide range of carboxylic acids could be esterified with primary alcohols by using EDCI, NaHCO(3), and Oxyma or Oxyma derivative 5b in 5% H(2)O-CH(3)CN. Oxyma derivative 5b is particularly useful, since it could be removed after the reaction via a simple basic or an acidic aqueous workup procedure.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563398 | PMC |
| http://dx.doi.org/10.1021/ol3022337 | DOI Listing |
Publication Analysis
Top Keywords
primary alcohols
12
oxyma derivative
12
selective esterifications
8
esterifications primary
8
oxyma oxyma
8
oxyma
5
alcohols water-containing
4
water-containing solvent
4
solvent oxyma
4
derivative 22-dimethyl-13-dioxolan-4-ylmethyl
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!