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Endothelium Modulates the Prothrombotic Phenotype of Factor V Leiden: Evidence From an Ex Vivo Model.
Arterioscler Thromb Vasc Biol
January 2025
Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Germany.
Background: Clinical expressivity of the thrombophilic factor V Leiden (FVL) mutation is highly variable. Recently, we demonstrated an increased APC (activated protein C) response in asymptomatic FVL carriers compared with FVL carriers with a history of venous thromboembolism (VTE) after in vivo coagulation activation. Here, we further explored this association using a recently developed ex vivo model based on patient-specific endothelial colony-forming cells (ECFCs).
View Article and Find Full Text PDFAre very high rates of exogenous carbohydrate ingestion (>90 g/hr) sufficient or indeed necessary to run a sub-2hr marathon? An analysis of the model predictions of Lukasiewicz and colleagues.
Front Nutr
January 2025
Department of Exercise Science, Grove City College, Grove City, PA, United States.
Multimodal machine learning for analysing multifactorial causes of disease-The case of childhood overweight and obesity in Mexico.
Front Public Health
January 2025
Karolinska Institutet, Department of Medicine Solna, Division of Clinical Epidemiology, Stockholm, Sweden.
Background: Mexico has one of the highest global incidences of paediatric overweight and obesity. Public health interventions have shown only moderate success, possibly from relying on knowledge extracted using limited types of statistical data analysis methods.
Purpose: To explore if multimodal machine learning can enhance identifying predictive features from obesogenic environments and investigating complex disease or social patterns, using the Mexican National Health and Nutrition Survey.
Elevated intraocular pressure associated with sauna use: A case report.
Am J Ophthalmol Case Rep
March 2025
Department of Ophthalmology, University of Colorado School of Medicine, 1675 North Aurora Ct, Aurora, CO, 80045, USA.
Purpose: To report a case of increased intraocular pressure following sauna use in a patient with severe-stage primary open-angle glaucoma.
Observations: A 64-year-old Hispanic male with severe-stage primary open-angle glaucoma experienced intraocular pressure spikes following sauna sessions, as detected in clinic and confirmed by a home tonometry device. The intraocular pressure spikes resolved after combined goniotomy and glaucoma drainage device implantation.
Elevated estradıol ın a prepubertal female: wıthın-laboratory systematıc and practıcal ınterference screenıng.
Scand J Clin Lab Invest
January 2025
Department of Medical Biochemistry, Ministry of Health, Ankara Bilkent City Hospital, Ankara, Turkey.
Analytical errors related to endogenous or exogenous substances are a cause of unnecessary investigation, intervention, and patient concern especially in immunoassay platforms. In this report, we systematically screened for estradiol interference using a practical algorithm. For extended research in interference screening, repeated estradiol measurements for control and case samples were carried out for method comparison (three immunoassay platforms and one liquid chromatography-mass spectrometry (LC-MS/MS) measurement), dilution test, polyethylene glycol (PEG) precipitation, and heterophile antibody blocking tube.
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