AI Article Synopsis
- APOE is known to increase the risk of late-onset Alzheimer's disease (LOAD), and recent studies have identified additional genes linked to the disease, primarily in European populations.
- A study examined the association of seven identified genes with LOAD in a Japanese population using data from 825 cases and 2934 controls, focusing on the impact of the APOE and PICALM genes.
- Results showed that APOE-ε4 carriers had a significantly higher risk for LOAD, while a variant in the PICALM gene was also associated with the disease, indicating it may be a risk factor in the Japanese population as well.
Article Abstract
APOE is an established susceptibility gene for late-onset Alzheimer's disease (LOAD). Recent genome-wide association studies have identified many additional susceptibility genes for LOAD in populations of European descent. However, there is little information on whether or not genetic variants in these genes are associated with other ethnicities. To investigate the association of seven genes identified by genome-wide association studies, we carried out a case-control study using 825 LOAD cases and 2934 controls in the Japanese population. For the APOE gene, APOE-ε4 carriers had a 4.54-fold higher risk than APOE-ε4 noncarriers after adjusting for age and sex (P=4.6×10(-27)). For other genes, the single-nucleotide polymorphism in the PICALM gene was significantly associated with LOAD (P=0.02, odds ratio=1.23). There was no significant interaction between PICALM and APOE-ε4 carrier status (P for interaction=0.68). Our data indicate that PICALM is also a susceptibility gene for LOAD in the Japanese population.
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| http://dx.doi.org/10.1097/YPG.0b013e3283586215 | DOI Listing |
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