AI Article Synopsis
- The study presents a straightforward method to create smart libraries of protein surface mimics that represent discontinuous epitopes, specifically in HIV-gp120.
- Researchers used a technique called CuAAC to attach up to three cyclic peptides to a triazacyclophane scaffold molecule, allowing for the effective representation of these protein mimics.
- These protein mimics have potential applications in developing synthetic vaccines and other related areas.
Article Abstract
We describe rapid and convenient access to smart libraries of protein surface discontinuous epitope mimics. Up to three different cyclic peptides, representing discontinuous epitopes in HIV-gp120, were conjugated to a triazacyclophane scaffold molecule via CuAAC. In this way protein mimics for use as synthetic vaccines and beyond will become available.
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| http://dx.doi.org/10.1039/c2cc35310e | DOI Listing |
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