AI Article Synopsis
- Lung and breast cancer can spread to the meninges, leading to meningeal metastases and various central nervous system defects based on tumor location.
- Diagnosis is confirmed by identifying cancer cells in the cerebrospinal fluid through cytological examination.
- Without treatment, patients typically have a prognosis of only weeks to months; however, intrathecal methotrexate chemotherapy for breast cancer-related meningeal carcinomatosis can improve survival and quality of life for about 50% of patients.
Article Abstract
Lung and breast cancer can give meningeal metastases. Clinical manifestations of leptomeningeal carcinomatosis include all forms of defect of the central nervous system depending on the localization of carcinomatous foci. Diagnosis is based on the detection of carcinomatous cells by the cytological examination of the cerebrospinal fluid. Without treatment the prognosis is limited to only some weeks or months. In case the meningeal carcinomatosis is related to breast cancer, intrathecal methotrexate chemotherapy may allow a significant survival benefit and improve the quality of life in about half of the patients.
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| http://dx.doi.org/10.1556/OH.2012.29439 | DOI Listing |
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