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Investigating heading representation in the zebrafish interpeduncular nucleus (2024 FENS-Kavli network of excellence PhD thesis prize).
Eur J Neurosci
December 2024
Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems, Rovereto, Italy.
The brain's ability to integrate sensory and motor information allows us to maintain a sense of orientation in space, a process in which head-direction cells play a key role. While these neurons have been studied extensively in mammals, their presence and function in non-mammalian species remain less understood. Here, I summarize the research work for my PhD thesis, where we explore the interpeduncular nucleus (IPN) in zebrafish, a lesser known brain region, using whole-brain electron microscopy and calcium imaging techniques.
View Article and Find Full Text PDFMechanisms of aquaporin-4 vesicular trafficking in mammalian cells.
J Neurochem
February 2024
College of Health and Life Sciences, Aston University, Birmingham, UK.
The aquaporin-4 (AQP4) water channel is abundantly expressed in the glial cells of the central nervous system and facilitates brain swelling following diverse insults, such as traumatic injury or stroke. Lack of specific and therapeutic AQP4 inhibitors highlights the need to explore alternative routes to control the water permeability of glial cell membranes. The cell surface abundance of AQP4 in mammalian cells fluctuates rapidly in response to changes in oxygen levels and tonicity, suggesting a role for vesicular trafficking in its translocation to and from the cell surface.
View Article and Find Full Text PDFIn conversation with Carol Robinson.
FEBS J
September 2023
Department of Chemistry, University of Oxford, UK.
Dame Carol Robinson is a professor of chemistry and Director of the Kavli Institute for Nanoscience Discovery at the University of Oxford. Carol's career in science began at the age of 16 as a lab technician at Pfizer (based in Kent), during which time she studied part-time and took evening classes to obtain a degree in chemistry. This was followed by a master's degree at the University of Swansea and a PhD at the University of Cambridge.
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