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Mechanisms for resistance to BCMA-targeted immunotherapies in multiple myeloma.
Blood Rev
January 2025
Department of Hematology, First Hospital of Jilin University, Changchun, Jilin, China. Electronic address:
Multiple myeloma (MM) remains incurable and patients eventually face the relapse/refractory dilemma. B cell maturation antigen (BCMA)-targeted immunotherapeutic approaches have shown great effectiveness in patients with relapsed/refractory MM, mainly including chimeric antigen receptor T cells (CAR-T), bispecific T cell engagers (TCEs), and antibody-drug conjugates (ADCs). However, their impact on long-term survival remains to be determined.
View Article and Find Full Text PDFEffects of Fecal Sewage and Antibiotic Exposure Stress on the Intestinal Microflora of Weaned Tibetan Piglets.
Microb Pathog
January 2025
Animal Science College, Tibet Agriculture & Animal Husbandry University, Linzhi, 860000, China; The Provincial and Ministerial Co-founded Collaborative Innovation Center for R & D in Tibet Characteristic Agricultural and Animal Husbandry Resources, Linzhi 860000, China. Electronic address:
Unregulated pig farming practices expose pigs to fecal sewage and antibiotic stress, which are common health risk factors. Thus, its effects on the animals' intestinal microflora were investigated herein. In total, 2,315,563 high-quality sequences were obtained via amplitude sequencing and, after OUT clustering, the fecal sewage group was identified to have the highest number and the antibiotic exposure group the lowest.
View Article and Find Full Text PDFChapter 10: WHAT PARATHYROID IMAGING IS REQUIRED FOR HYPERPARATHYROIDISM?
Ann Endocrinol (Paris)
January 2025
Endocrinology Federation, Hôpital Louis Pradel, 28 Avenue doyen Lépine, 69500 Bron, Hospices Civils de Lyon and Université Lyon 1, France. Electronic address:
In over 80% of cases, primary hyperparathyroidism results from hypersecretion of PTH by a single parathyroid adenoma. Multi-glandular involvement, combining adenoma and/or hyperplasia in varying proportions, is also possible, although less frequent. When the diagnosis of hyperparathyroidism is certain and surgery is envisaged, imaging is useful for locating the hyperfunctioning gland or glands.
View Article and Find Full Text PDFChapter 7: CLINICAL FORMS AT DIFFERENT AGES OF LIFE: CHILDHOOD, PREGNANCY, LACTATION, OLD AGE.
Ann Endocrinol (Paris)
January 2025
Université Paris-Saclay, Inserm, Endocrine Physiology and Physiopathology, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction and Centre de Référence des Maladies Rares de l'Hypophyse HYPO, F-94270 Le Kremlin-Bicêtre, France. Electronic address:
Primary hyperparathyroidism is rare in children. A germline mutation is identified in half of all children with primary hyperparathyroidism (70% of newborns and infants, and 40% of children and adolescents). The clinical manifestations of primary hyperparathyroidism in children are highly variable (often absent in newborns, rather severe and symptomatic in children and adolescents) and depend on the genetic cause, as well as the severity, rapidity of onset and duration of hypercalcemia.
View Article and Find Full Text PDFImpact of fall ammonia fluctuations on winter nitrification in moving bed biofilm reactors.
Sci Total Environ
January 2025
Nexom, Winnipeg, Manitoba R2J 3R8, Canada.
This pilot-scale study investigated nitrifying moving bed biofilm reactors (MBBRs) in a post-lagoon treatment setup over two years to evaluate the impact of seasonal ammonia fluctuations on winter nitrification. In Year 2, reactors without fall ammonia starvation achieved significantly higher winter ammonia removal (97.2 ± 1.
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