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resensitization of multidrug-resistant clinical isolates of and through phage-antibiotic synergy.
Antimicrob Agents Chemother
December 2024
Department of Pathology, University of California, San Diego, California, USA.
Bacteriophages are an increasingly attractive option for the treatment of antibiotic-resistant infections, but their efficacy is difficult to discern due to the confounding effects of antibiotics. Phages are generally delivered in conjunction with antibiotics, and thus, when patients improve, it is unclear whether the phages, antibiotics, or both are responsible. This question is particularly relevant for enterococcus infections, as limited data suggest phages might restore antibiotic efficacy against resistant strains.
View Article and Find Full Text PDFPRIDASE 2024 guidelines for reporting diagnostic accuracy studies in endodontics: Explanation and elaboration.
Int Endod J
January 2025
School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.
Article Synopsis
- The PRIDASE 2024 guidelines are designed to enhance the reporting of diagnostic accuracy studies in endodontics, building on the existing STARD 2015 guidelines and CLIP principles with a focus on endodontic-specific items.
- These guidelines include a checklist with 11 domains and 66 items that aim to reduce bias and improve study quality during the peer review process.
- The document offers detailed explanations for each checklist item, supported by literature examples to aid manuscript developers, along with access links to the full guidelines on the PRIDE and International Endodontic Journal websites.
Dignity enhanced through faith & family support in palliative care: a qualitative study.
BMC Palliat Care
June 2024
International Observatory on End-of-Life Care, Division of Health Research, Faculty of Health and Medicine, Lancaster University, Sir John Fisher Drive, Lancaster, LA1 4YW, UK.
Background: Dignity is integral to palliative care. Illness can diminish it, causing hopelessness and the wish to hasten death. Yet, dignity is a complex multidimensional phenomenon, influenced by values and context.
View Article and Find Full Text PDFA simple solid media assay for detection of synergy between bacteriophages and antibiotics.
Microbiol Spectr
May 2024
Department of Pathology, University of California San Diego, La Jolla, California, USA.
The emergence of antibiotic-resistant bacteria (ARB) has necessitated the development of alternative therapies to deal with this global threat. Bacteriophages (viruses that target bacteria) that kill ARB are one such alternative. Although phages have been used clinically for decades with inconsistent results, a number of recent advances in phage selection, propagation, and purification have enabled a reevaluation of their utility in contemporary clinical medicine.
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