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Identification of the Determinants of Plexiform Neurofibroma Morbidity in Pediatric and Young Adult Neurofibromatosis Type 1 Patients: A Pilot Multivariate Approach.
Cancers (Basel)
January 2025
Sophia, Department of General Pediatrics, Erasmus MC, 3015 GD Rotterdam, The Netherlands.
Background: Plexiform neurofibromas (PNs) are histologically benign peripheral nerve sheath tumors associated with neurofibromatosis type 1 (NF1) and often lead to significant morbidity due to growth. Management includes watchful waiting, surgery for partial debulking, and, since recently, systemic treatment with MEK inhibitors. However, due to the scarcity of natural history studies, our understanding of the natural progression of PNs to guide clinicians in deciding in whom and when to intervene is scarce.
View Article and Find Full Text PDFCommon neocortical and hippocampal correlates of Performance errors in a timing task.
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January 2025
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102.
We aimed to identify the neuronal correlates of performance errors in a difficult timing task. Male rats were trained to seek ewards and avoid hocks depending on the position of photic conditioned stimuli (CS- and CS-, respectively). Then, they were exposed to conflict trials where they had to time the interval between the CS-R and CS-S to obtain rewards while avoiding footshocks.
View Article and Find Full Text PDFGonadotropin-releasing hormone agonist protocols for pituitary suppression in assisted reproduction.
Cochrane Database Syst Rev
January 2025
Institute of Education in Healthcare and Medical Sciences, University of Aberdeen, Aberdeen, UK.
Background: Gonadotropin-releasing hormone agonists (GnRHa) are commonly used in assisted reproduction technology (ART) cycles to prevent a luteinising hormone (LH) surge during controlled ovarian hyperstimulation (COH) prior to planned oocyte retrieval, thus optimising the chances of live birth. We compared the benefits and risks of the different GnRHa protocols used.
Objectives: To evaluate the effectiveness and safety of different GnRHa protocols used as adjuncts to COH in women undergoing ART.
Only Children by Choice vs. Only Children by Circumstances: Why Do Some Women Have Only One Child?
Reprod Sci
January 2025
Department of Management, London School of Economics and Political Science, Houghton Street, London, WC2A 2AE, UK.
In an attempt to stimulate further theory and research on only children, we introduce two conceptual distinctions: Only children as independent variables vs. only children as dependent variables; and only children by choice vs. only children by circumstances.
View Article and Find Full Text PDFSuccessful venous thrombectomy for extensive cerebral venous and sinus thrombosis after failed diagnostic lumbar puncture.
Rofo
January 2025
Department of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany.
With an incidence of 2-5 per million adults, cerebral venous and sinus thrombosis (CVST) is a rarity in the spectrum of cerebrovascular diseases. The etiology and symptomatic presentation are heterogeneous and diverse. CSVT is, therefore, often underdiagnosed.
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