AI Article Synopsis
- Characterization of polymerized liposomes (PolyPIPosomes) is achieved using a combination of normal dc electrical field-flow fractionation and cyclical electrical field-flow fractionation (CyElFFF), which streamlines the analytical process.
- CyElFFF employs an oscillating electric field for separation within the same channel as standard techniques, providing an effective method for assessing nanoparticles' sizes and electrophoretic mobilities.
- The study demonstrates the system's capability to quantify both particle size and mobility distributions, marking the first report of effective separation at low applied voltages.
Article Abstract
Characterization of polymerized liposomes (PolyPIPosomes) was carried out using a combination of normal dc electrical field-flow fractionation and cyclical electrical field-flow fractionation (CyElFFF) as an analytical technique. The constant nature of the carrier fluid and channel configuration for this technique eliminates many variables associated with multidimensional analysis. CyElFFF uses an oscillating field to induce separation and is performed in the same channel as standard dc electrical field-flow fractionation separation. Theory and experimental methods to characterize nanoparticles in terms of their sizes and electrophoretic mobilities are discussed in this paper. Polystyrene nanoparticles are used for system calibration and characterization of the separation performance, whereas polymerized liposomes are used to demonstrate the applicability of the system to biomedical samples. This paper is also the first to report separation and a higher effective field when CyElFFF is operated at very low applied voltages. The technique is shown to have the ability to quantify both particle size and electrophoretic mobility distributions for colloidal polystyrene nanoparticles and PolyPIPosomes.
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