Pre- and postoperative treatment was conducted in 140 patients with trophic ulcers in a controlled abacterial medium in the period from 1985 to 1988. The etiological factor of the development of the trophic ulcer was primary varicosity in 86 (61.4%) and the post-thrombophlebitic syndrome in 54 (38.5%) patients. Venous hemodynamics improved both on the healthy and on the affected extremity. Besides, there was a tendency towards a decrease of the blood proteolytic activity near the focus of affection and an increase of that in the peripheral blood.

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