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HMGB1 lactylation drives neutrophil extracellular trap formation in lactate-induced acute kidney injury.
Front Immunol
January 2025
Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Rationale: Acute kidney injury (AKI) is a clinical syndrome associated with a multitude of conditions. Although renal replacement therapy (RRT) remains the cornerstone of treatment for advanced AKI, its implementation can potentially pose risks and may not be readily accessible across all healthcare settings and regions. Elevated lactate levels are implicated in sepsis-induced AKI; however, it remains unclear whether increased lactate directly induces AKI or elucidates the underlying mechanisms.
View Article and Find Full Text PDFEverything but the Kitchen Sink: A Mixed Methods Approach to Health IT Usability Testing.
Proc Hum Factors Ergon Soc Annu Meet
November 2019
National Center for Human Factors in Healthcare, MedStar Health, Washington DC, USA.
Usability testing has become a necessary step to successfully implement health information technology, but despite the expanded variety of usability methods, systems still are not guaranteed to meet user needs in a hectic and dynamic healthcare environment. The present work discusses some of the metrics employed with the intent of usability testing clinical decision support alerts for the early identification of sepsis patients. By utilizing methods such as eye tracking, think aloud protocols, human computer interaction, and more, health information technology can be adequately developed to ensure effective, efficacious, and optimal integration.
View Article and Find Full Text PDFAssociation of early aspirin use with 90-day mortality in patients with sepsis: an PSM analysis of the MIMIC-IV database.
Front Pharmacol
January 2025
Department of Anesthesiology, Ningbo Medical Center Lihuili Hospital, Medical School of Ningbo University, Ningbo, China.
Objective: In addition to its antiplatelet and anti-inflammatory properties, aspirin inhibits bacterial proliferation directly. The potential benefits of aspirin may enhance the prognosis for sepsis patients. However, little is known about the effects of early aspirin administration.
View Article and Find Full Text PDFThe potential of melatonin in sepsis-associated acute kidney injury: Mitochondrial protection and cGAS-STING signaling pathway.
Heliyon
January 2025
Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213000, Jiangsu, China.
Melatonin (Mel) is known for various biological function, such as antioxidant and anti-inflammatory capabilities, as well as its ability to modulate immune responses, which can protect mitochondria and improve the prognosis of sepsis-associated acute kidney injury (SA-AKI). However, there is a multitude of theories regarding how Mel exerts its immune-modulating functions, with no consensus reached as of yet. We propose the protective effects of Mel on mitochondria are closely related to the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway in the immune-inflammatory response.
View Article and Find Full Text PDFPhenotypic and genetic extended spectrum beta lactamase profiles of bacterial isolates from ICU in tertiary level hospital in Kenya.
F1000Res
January 2025
Department of Human Pathology, University of Nairobi, Nairobi, Nairobi County, Kenya.
Background: Bacterial infections in the Intensive Care Units are a threat to the lives of critically ill patients. Their vulnerable immunity predisposes them to developing bacteria-associated sepsis, deteriorating their already fragile health. In the face of increasing antibiotics resistance, the problem of bacterial infection in ICU is worsening.
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